NCT07477574

Brief Summary

This study aims to develop a muscle-specific multimodal artificial intelligence (AI) model for the diagnosis of sarcopenia and to investigate the effects of rehabilitation training on muscle aging. Clinical, functional, and imaging data will be collected from participants with muscle function decline. Multimodal data, including muscle function measurements and clinical assessments, will be integrated to develop and validate an AI-based diagnostic model for sarcopenia. In addition, the effects of rehabilitation training on muscle function and muscle aging-related outcomes will be evaluated. The results of this study are expected to contribute to the development of digital biomarkers and precision rehabilitation strategies for sarcopenia.

Trial Health

65
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
75

participants targeted

Target at P50-P75 for not_applicable

Timeline
21mo left

Started Mar 2026

Typical duration for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress11%
Mar 2026Feb 2028

Study Start

First participant enrolled

March 1, 2026

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

March 9, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

March 17, 2026

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2028

Last Updated

March 17, 2026

Status Verified

March 1, 2026

Enrollment Period

2 years

First QC Date

March 9, 2026

Last Update Submit

March 12, 2026

Conditions

Sarcopenia

Keywords

SarcopeniaMuscle agingMultimodal AIMuscle function

Outcome Measures

Primary Outcomes (1)

  • AI model performance

    The performance of the muscle-specific multimodal artificial intelligence (AI) model for detecting sarcopenia will be evaluated using the Area Under the Receiver Operating Characteristic Curve (AUC). The AUC evaluates the ability of the AI model to discriminate between participants with and without sarcopenia(e.g., handgrip strength, gait speed, and appendicular skeletal muscle mass). The AUC value ranges from 0.5 to 1.0, where higher values indicate better discrimination performance of the AI model.

    Baseline to 12 weeks after rehabilitation training

Secondary Outcomes (8)

  • Five-Times Chair Stand Test (5×STS)

    Baseline to 12 weeks after rehabilitation training

  • Gait Speed

    Baseline to 12 weeks after rehabilitation training

  • Appendicular Skeletal Muscle Mass (DEXA)

    Baseline to 12 weeks after rehabilitation training

  • Appendicular Skeletal Muscle Mass (BIA)

    Baseline to 12 weeks after rehabilitation training

  • Sarcopenia Screening

    Baseline to 12 weeks after rehabilitation training

  • +3 more secondary outcomes

Study Arms (1)

Rehabilitation Training

EXPERIMENTAL

Participants will undergo a structured rehabilitation training program aimed at improving muscle function and reducing muscle aging-related decline.

Behavioral: Rehabilitation training

Interventions

Rehabilitation trainingBEHAVIORAL

Participants will perform a structured rehabilitation training program designed to improve muscle strength, physical performance, and muscle function. Clinical assessments and muscle function measurements will be collected before and after the rehabilitation program to evaluate the effects of training and to support the development of a muscle-specific multimodal AI model for sarcopenia diagnosis.

Rehabilitation Training

Eligibility Criteria

Age65 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may qualify if:

  • Adults aged 65 years or older
  • Individuals with reduced muscle function or at risk of sarcopenia
  • Able to participate in rehabilitation training
  • Able to understand the study procedures and provide written informed consent

You may not qualify if:

  • Severe cardiovascular, neurological, or musculoskeletal conditions that limit participation in exercise
  • Severe cognitive impairment
  • Participation in other clinical trials that may influence study outcomes
  • Any medical condition judged by the investigator to make participation unsafe

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular AtrophyNeuromuscular ManifestationsNeurologic ManifestationsNervous System DiseasesAtrophyPathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsSigns and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

March 9, 2026

First Posted

March 17, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

February 28, 2028

Study Completion (Estimated)

February 28, 2028

Last Updated

March 17, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share