Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis

NCT07762664 | Recruiting

• 1 other identifier: PCD-CT Carotid Artery
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of carotid atherosclerotic plaques in patients with carotid artery stenosis.

Conditions

Carotid Artery Stenosis; Carotid Atherosclerosis; Carotid Atherosclerotic Plaque

Keywords

Photon-Counting CT; Carotid Artery Stenosis; Plaque Characterization; Carotid Plaque

Outcome Measures

Primary Outcomes (1)

• Carotid Plaque Visualization and Characterization on PCD-CTA Compared With Conventional EID-CTA

  Carotid atherosclerotic plaques will be independently evaluated on photon-counting detector CTA and conventional energy-integrating detector CTA.

  1-4 years

Secondary Outcomes (1)

• Image Quality

  At the preprocedural CT examination, before carotid artery stenting

Study Arms (1)

Patients With Carotid Artery Stenosis

Patients with carotid artery stenosis who undergo preprocedural carotid CT angiography will be prospectively enrolled. Carotid plaque characteristics and image quality will be evaluated and compared between photon-counting detector CT angiography and conventional energy-integrating detector CT angiography.

Eligibility Criteria

• Age: 10 Years - 90 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of patients with carotid atherosclerotic stenosis referred for carotid CT angiography. Eligible participants will be prospectively enrolled before carotid artery intervention.

You may qualify if:

• \- Presence or clinical suspicion of carotid atherosclerotic stenosis requiring carotid CT angiography.
• Ability to provide written informed consent. Adequate image quality for carotid plaque analysis.

You may not qualify if:

• \- Known contraindication to iodinated contrast material. Severe renal dysfunction precluding contrast-enhanced CT according to institutional clinical criteria.
• Pregnancy. Severe motion or other imaging artifacts resulting in nondiagnostic image quality.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

RECRUITING

MeSH Terms

Conditions

Carotid Stenosis; Carotid Artery Diseases

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Xin Lou

  Chinese PLA General Hospital

  STUDY CHAIR

Central Study Contacts

Jinhao Lyu, MD

CONTACT

+8615903562929; 330322990@qq.com

Jinying He

CONTACT

1527012389@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chairman

Study Record Dates

• First Submitted: August 8, 2026
• First Posted: August 13, 2026
• Study Start: January 7, 2026
• Primary Completion (Estimated): January 7, 2029
• Study Completion (Estimated): January 7, 2029
• Last Updated: August 13, 2026

Record last verified: 2026-08

Locations

CN (1)