Lung Ultrasound With Acute Exacerbation and Stable COPD

NCT07757126 | Completed

• 1 other identifier: 2026/7-14
• Study Type: observational
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-sectional study aims to compare lung ultrasound findings, functional capacity, and dyspnea among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), patients with stable COPD, and healthy controls. The study will include approximately 60 participants divided into three groups (acute exacerbation COPD, stable COPD, and healthy controls). Participants will undergo comprehensive assessments including lung ultrasound, pulmonary function tests, the Modified Borg Scale, the Modified Medical Research Council (mMRC) Dyspnea Scale, the 6-Minute Walk Test, the 1-Minute Sit-to-Stand Test, the COPD Assessment Test (CAT), the Charlson Comorbidity Index, and the BODE Index. The primary objective is to determine differences in lung ultrasound abnormalities, particularly B-lines, consolidations, and lung ultrasound scores, and to investigate their relationship with functional capacity and dyspnea severity. The findings are expected to clarify the clinical utility of lung ultrasound as a non-invasive bedside assessment tool for evaluating disease severity and supporting comprehensive management of patients with COPD.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

Chronic Obstructive Pulmonary Disease (COPD); Acute Exacerbation; Lung Ultrasound; Functional Capacity; Dyspnea

Outcome Measures

Primary Outcomes (1)

• Lung Ultrasound Score

  Total lung ultrasound score (0-36) obtained using a standardized 12-zone lung ultrasound protocol. The score reflects the degree of lung aeration loss based on the presence of A-lines, B-lines, confluent B-lines, and consolidations.

  Baseline (Cross-sectional assessment)

Secondary Outcomes (16)

• Six-Minute Walk Distance (6MWD)

  Baseline

• One-Minute Sit-to-Stand Test

  Baseline

• Modified Borg Dyspnea Scale

  Baseline

• Modified Medical Research Council (mMRC) Dyspnea Scale

  Baseline

• COPD Assessment Test (CAT)

  Baseline

Study Arms (3)

Acute Exacerbation COPD

Patients diagnosed with chronic obstructive pulmonary disease (COPD) who are experiencing an acute exacerbation. Participants will undergo lung ultrasound, pulmonary function testing, functional capacity assessment (6-Minute Walk Test and 1-Minute Sit-to-Stand Test), dyspnea evaluation (Modified Borg Scale and mMRC Dyspnea Scale), COPD Assessment Test (CAT), Charlson Comorbidity Index, and BODE Index.

Stable COPD

Patients with clinically stable chronic obstructive pulmonary disease (COPD) without an acute exacerbation. Participants will undergo the same assessments as the acute exacerbation group, including lung ultrasound, pulmonary function testing, functional capacity tests, dyspnea evaluation, CAT, Charlson Comorbidity Index, and BODE Index.

Healthy Controls

Age-matched healthy individuals without chronic pulmonary disease or other significant cardiopulmonary, neurological, orthopedic, or psychiatric disorders. Participants will undergo lung ultrasound, pulmonary function testing, functional capacity assessment, and dyspnea evaluation using the same standardized procedures as the COPD groups.

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 40-75 years will be recruited from Munzur University and Tunceli State Hospital. The study population will consist of three groups: patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), patients with clinically stable COPD, and age-matched healthy controls. Eligible participants will be enrolled consecutively after providing written informed consent and will undergo standardized assessments, including lung ultrasound, pulmonary function testing, functional capacity tests, dyspnea evaluation, and psychological assessments.

You may qualify if:

• Acute Exacerbation COPD Group
• Adults aged 40-65 years.
• Diagnosis of chronic obstructive pulmonary disease (COPD) according to GOLD criteria.
• Currently experiencing an acute exacerbation of COPD.
• Able and willing to provide written informed consent.
• Stable COPD Group
• Adults aged 40-75 years.
• Diagnosis of chronic obstructive pulmonary disease (COPD) according to GOLD criteria.
• Clinically stable without an acute exacerbation at the time of assessment.
• Able and willing to provide written informed consent.
• Healthy Control Group
• Adults aged 40-65 years.
• No history of chronic pulmonary disease.
• Able and willing to provide written informed consent.

You may not qualify if:

• Presence of cardiovascular, neurological, orthopedic, psychiatric, or other systemic diseases that may affect study assessments.
• Cognitive impairment or psychological conditions preventing completion of study procedures.
• History of thoracic or major surgery that could influence pulmonary function or lung ultrasound findings.
• Pregnancy.
• Inability to perform pulmonary function testing or functional exercise tests.
• Refusal or inability to provide written informed consent.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Munzur University Faculty of Health Sciences

Tunceli, Turkey (Türkiye)

Location

Related Publications (1)

• Volpicelli G, Elbarbary M, Blaivas M, Lichtenstein DA, Mathis G, Kirkpatrick AW, Melniker L, Gargani L, Noble VE, Via G, Dean A, Tsung JW, Soldati G, Copetti R, Bouhemad B, Reissig A, Agricola E, Rouby JJ, Arbelot C, Liteplo A, Sargsyan A, Silva F, Hoppmann R, Breitkreutz R, Seibel A, Neri L, Storti E, Petrovic T; International Liaison Committee on Lung Ultrasound (ILC-LUS) for International Consensus Conference on Lung Ultrasound (ICC-LUS). International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med. 2012 Apr;38(4):577-91. doi: 10.1007/s00134-012-2513-4. Epub 2012 Mar 6.

  PMID: 22392031 BACKGROUND

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Dyspnea

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: August 2, 2026
• First Posted: August 11, 2026
• Study Start: May 18, 2026
• Primary Completion: July 20, 2026
• Study Completion: July 30, 2026
• Last Updated: August 11, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)