Investigation of the Acute Effects of Traditional and Functional IMT on Muscle Oxygenation in COPD

NCT07267923 | Completed

• 1 other identifier: 2025/489
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effects of functional and conventional inspiratory muscle training (IMT) on post-exercise muscle deoxygenation in individuals with Chronic Obstructive Pulmonary Disease (COPD). Participants will complete both training modalities on separate days. A 2-minute walk test (2MWT) will be performed baseline, and after each session. Muscle oxygenation (SmO₂) will be assessed using near-infrared spectroscopy . Dyspnea and fatigue will be evaluated with the Modified Borg Scale, and heart rate and oxygen saturation (SpO₂) will be measured by pulse oximetry. Measurements will be recorded before, after training and at the end of the walking test.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

Chronic Obstructive Pulmonary Disease; inspiratory muscle training; functional inspiratory muscle training

Outcome Measures

Primary Outcomes (1)

• Muscle oxygenation levels (SmO₂)

  Muscle oxygenation (SmO₂) will be assessed using near-infrared spectroscopy .

  1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

Secondary Outcomes (5)

• Fatigue

  1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

• Dyspnea

  1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

• Heart rate

  1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

• Saturation (SPO2)

  1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

• hemoglobin

  1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

Study Arms (1)

Chronic Obstructive Pulmonary Disease

EXPERIMENTAL

Other: Traditional inspiratory muscle training; Other: Functional inspiratory muscle training (IMT)

Interventions

Functional inspiratory muscle training (IMT) OTHER

Functional inspiratory muscle training (IMT) is defined as inspiratory muscle training performed while maintaining core stabilization and postural control. Functional IMT consists of a warm-up period, core exercises, dynamic trunk activation combined with upper extremity movements, postural control exercises, and a cool-down period. The participant performs these exercises simultaneously with inspiratory muscle training.

Chronic Obstructive Pulmonary Disease

Traditional inspiratory muscle training OTHER

Traditional inspiratory muscle training is a form of training performed using a resistive breathing device that provides resistance to the muscles involved in inspiration. Inspiratory muscle training will be performed using a portable pressure-threshold device (POWERbreathe Classic IMT - Light Resistance). IMT will be administered in a seated position with upper extremities supported and the upper chest/shoulders relaxed. The training procedure will be explained to each participant and performed for 15 minutes at 40% of the maximal inspiratory pressure (MIP).

Chronic Obstructive Pulmonary Disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being 18 years of age or older,
• Having a diagnosis of COPD,
• Being in stage II-III according to the GOLD classification,
• Being able to mobilize independently.

You may not qualify if:

• Having a recent exacerbation or complication requiring hospitalization,
• Having had a respiratory tract infection within the past month,
• Having any disease or medical condition that prevents participation in exercise, -Having cognitive impairment (a score of \<24 on the Mini-Mental Test).

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

Gulhane Faculty of Physiotherapy and Rehabilitation

Ankara, Keçiören, 06018, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This study uses a crossover design with a single participant group, in which all participants receive both exercise interventions. Each participant will undergo one baseline assessment prior to any intervention. On separate days, participants will complete two different inspiratory muscle training (IMT) interventions: conventional IMT and functional IMT. A standardized outcome assessment is performed immediately after each intervention session, resulting in a total of three measurement time points (pre-intervention, post-conventional IMT, and post-functional IMT). Outcomes obtained at these three time points will be compared to determine the acute effects and relative impact of each training modality.

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: December 5, 2025
• Study Start: November 11, 2025
• Primary Completion: January 1, 2026
• Study Completion: February 15, 2026
• Last Updated: April 9, 2026

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)