NCT07756775

Brief Summary

This prospective observational study aims to compare the diagnostic performance of non-contrast magnetic resonance angiography (NC-MRA) and carotid Doppler ultrasonography in the evaluation of carotid artery disease among patients with ischemic cerebrovascular stroke or transient ischemic attack. A total of 200 adult patients presenting to Sohag University Hospital will undergo both imaging modalities. The study will assess the agreement between NC-MRA and carotid Doppler in detecting and grading carotid artery stenosis according to the NASCET criteria, with the goal of evaluating the clinical utility of each technique and optimizing imaging strategies for the assessment of cerebrovascular stroke.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
7mo left

Started Jul 2026

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress9%
Jul 2026Mar 2027

Study Start

First participant enrolled

July 20, 2026

Completed
6 days until next milestone

First Submitted

Initial submission to the registry

July 26, 2026

Completed
16 days until next milestone

First Posted

Study publicly available on registry

August 11, 2026

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2027

Expected
20 days until next milestone

Study Completion

Last participant's last visit for all outcomes

March 20, 2027

Last Updated

August 11, 2026

Status Verified

August 1, 2026

Enrollment Period

7 months

First QC Date

July 26, 2026

Last Update Submit

August 7, 2026

Conditions

Ischemic StrokeTransient Ischemic AttackCarotid Artery Stenosis (Symptomatic and Asymptomatic)

Outcome Measures

Primary Outcomes (1)

  • Internal Carotid Artery Stenosis Grade (according to NASCET criteria) assessed by Non-contrast Magnetic Resonance Angiography and Carotid Doppler ultrasonography.

    Internal carotid artery stenosis grade in patients with ischemic stroke or transient ischemic attack determined according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria using non-contrast magnetic resonance angiography and carotid Doppler ultrasonography. The stenosis grades obtained by the two imaging modalities will be compared.

    At the baseline imaging visit (within 7-14 days of symptom onset).

Study Arms (1)

Patients with Ischemic Stroke or Transient Ischemic Attack

Adult patients (≥18 years) with clinically diagnosed ischemic stroke or transient ischemic attack who undergo both carotid Doppler ultrasonography and non-contrast magnetic resonance angiography for evaluation of carotid artery disease. The findings of the two imaging modalities will be compared for the assessment of carotid artery stenosis and atherosclerotic plaque characteristics.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients (≥18 years) presenting to Sohag University Hospital with a clinical diagnosis of ischemic stroke or transient ischemic attack (TIA) who are eligible for magnetic resonance imaging and carotid Doppler ultrasonography.

You may qualify if:

  • Adults aged 18 years or older.
  • Clinically diagnosed ischemic stroke or transient ischemic attack (TIA).
  • Imaging performed within 7-14 days of symptom onset.
  • Hemodynamically stable and suitable for magnetic resonance imaging (MRI).
  • Able and willing to provide written informed consent.

You may not qualify if:

  • Hemorrhagic stroke.
  • Previous carotid artery stenting.
  • Contraindications to MRI, including:
  • Non-MRI-compatible pacemakers or other MRI-incompatible implants.
  • Cochlear implants.
  • MRI-incompatible metallic orthopedic implants.
  • Severe claustrophobia.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sohag University Hospital

Sohag, Sohag Governorate, 82524, Egypt

RECRUITING

Related Publications (1)

  • Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E; NHS Research and Development Health Technology Assessment Carotid Stenosis Imaging Group. Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet. 2006 May 6;367(9521):1503-12. doi: 10.1016/S0140-6736(06)68650-9.

    PMID: 16679163BACKGROUND

MeSH Terms

Conditions

Ischemic StrokeIschemic Attack, TransientCarotid Stenosis

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular DiseasesBrain IschemiaCarotid Artery DiseasesArterial Occlusive Diseases

Study Officials

  • Mohamed Tharwat Mahmoud, Professor

    Sohag University

    STUDY CHAIR

Central Study Contacts

Mohamed Saad Gad

CONTACT

+201112435154mohsaadgad@gmail.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Radiology Resident

Study Record Dates

First Submitted

July 26, 2026

First Posted

August 11, 2026

Study Start

July 20, 2026

Primary Completion (Estimated)

February 28, 2027

Study Completion (Estimated)

March 20, 2027

Last Updated

August 11, 2026

Record last verified: 2026-08

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)