Follow-up Extension Study of Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis

NCT07242768 | Recruiting DMC

• 1 other identifier: SPORTS1102
• Study Type: observational
• Target: 1,300
• Locations: 1 country
• Sites: 1

Brief Summary

This study will include the subjects with symptomatic intracranial arterial stenosis (ICAS) who have participated in and completed the 1-year follow-up of RESIST trial (NCT06615726). The aim is to observe the long-term clinical outcomes over 3 years after a 1-year regular physical exercise intervention in patients with symptomatic ICAS.

Conditions

Ischemic Stroke; Transient Ischemic Attack

Keywords

Ischemic Stroke; Transient Ischemic Attack; Symptomatic intracranial arterial stenosis

Outcome Measures

Primary Outcomes (1)

• New ischemic stroke events

  Within 3 years after randomization

Secondary Outcomes (9)

• New ischemic stroke and transient ischemic attack events in the responsible vessel supply area

  Within 3 years after randomization

• New ischemic stroke and transient ischemic attack events

  Within 3 years after randomization

• Hemorrhagic stroke events

  Within 3 years after randomization

• Myocardial infarction events

  Within 3 years after randomization

• Proportion of patients achieving modified Rankin Scale score (mRS) 0-1

  At 3 years after randomization

Study Arms (2)

Regular Physical Exercise Group

Participants with symptomatic ICAS who were assigned to the regular physical exercise intervention in the RESIST trial and completed the 12-month follow-up.

Other: Non-Interventional Study

Control Group

Participants with symptomatic ICAS who were assigned to the control group in the RESIST trial and completed the 12-month follow-up.

Other: Non-Interventional Study

Interventions

Non-Interventional Study OTHER

After completing 12-month intervention from RESIST trial, investigators would not make any interventions or impact on subjects.

Control Group; Regular Physical Exercise Group

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will include the subjects who enrolled in the RESIST trial.

You may qualify if:

• Participants who enrolled in the RESIST trial and completed the 12-month follow-up.
• Written informed consent to participate in this 3-year observational extension.

You may not qualify if:

• Participants who withdrew consent in the RESIST trial, decline to participate in this extension, or were lost to follow-up at 12 months.

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (1)

Xuanwu Hospital, Capital Medical University

Beijing, China

RECRUITING

MeSH Terms

Conditions

Ischemic Stroke; Ischemic Attack, Transient

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Brain Ischemia

Central Study Contacts

Xunming Ji

CONTACT

01083198962; jixm@ccmu.edu.cn

Chuanjie Wu

CONTACT

01083199439; wuchuanjie@ccmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Neurology, Xuanwu Hospital, Capital Medical University

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 21, 2025
• Study Start: January 10, 2026
• Primary Completion (Estimated): November 30, 2028
• Study Completion (Estimated): November 30, 2028
• Last Updated: January 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)