Minimally Invasive Non-Surgical Periodontal Treatment

NCT07755644 | Not Yet Recruiting

• 1 other identifier: ATAUNI-MINST-2026
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy in patients with Stage III/IV periodontitis. Twenty-three systemically healthy adults presenting with bilateral molar teeth exhibiting periodontal pockets ≥5 mm with bleeding on probing will be enrolled. In each participant, molar teeth will be randomly allocated to receive either conventional subgingival scaling and root planing (SRP) using ultrasonic instruments alone (control) or conventional SRP followed by MINST using Mini-Five Gracey curettes under magnification loupes (test). Clinical periodontal parameters, including Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL), will be evaluated at baseline, 3 months, and 6 months after treatment. The study will investigate whether MINST provides superior clinical outcomes compared with conventional non-surgical periodontal therapy.

Conditions

Periodontitis; Periodontitis (Stage 3)

Keywords

Periodontitis; Stage III Periodontitis; Stage IV Periodontitis; Minimally Invasive Non-Surgical Therapy; MINST; Scaling and Root Planing; Root Debridement

Outcome Measures

Primary Outcomes (1)

• Probing Pocket Depth (PPD)

  Change in probing pocket depth (PPD) measured in millimeters using a UNC-15 periodontal probe.

  Baseline, 3 months, and 6 months

Secondary Outcomes (4)

• Clinical Attachment Level (CAL)

  Baseline, 3 months, and 6 months

• Bleeding on Probing (BOP)

  Baseline, 3 months, and 6 months

• Plaque Index (PI)

  Baseline, 3 months, and 6 months

• BANA Test

  Baseline, 3 months, and 6 months

Study Arms (2)

MINST Group

EXPERIMENTAL

Participants assigned to the experimental arm will receive conventional non-surgical periodontal therapy with ultrasonic scaling and root planing followed by Minimally Invasive Non-Surgical Therapy (MINST) using Mini-Five Gracey curettes under magnification loupes. Treatment will be performed over two sessions separated by one week.

Procedure: Minimally Invasive Non-Surgical Therapy (MINST)

Conventional SRP Group

ACTIVE COMPARATOR

Participants assigned to the control arm will receive conventional non-surgical periodontal therapy consisting of subgingival scaling and root planing using ultrasonic instruments. Treatment will be performed over two sessions separated by one week.

Procedure: Conventional Scaling and Root Planing

Interventions

Minimally Invasive Non-Surgical Therapy (MINST) PROCEDURE

Minimally Invasive Non-Surgical Therapy (MINST) consists of subgingival scaling and root planing performed using Mini-Five Gracey curettes under ×4.0 magnification loupes following conventional ultrasonic instrumentation. The procedure is designed to minimize soft tissue trauma while improving access to deep periodontal pockets and root surface debridement. Treatment is completed in two sessions separated by one week.

MINST Group

Conventional Scaling and Root Planing PROCEDURE

Conventional non-surgical periodontal therapy consisting of subgingival scaling and root planing performed using ultrasonic instruments. Treatment is completed over two sessions separated by one week according to the study protocol.

Also known as: SRP

Conventional SRP Group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 18 to 35 years.
• Diagnosed with Stage III or Stage IV periodontitis.
• Systemically healthy.
• Presence of at least two bilateral molar teeth with probing pocket depth (PPD) ≥5 mm and bleeding on probing (BOP).
• At least 20 remaining teeth.
• Radiographic evidence of periodontal bone loss.
• Non-smokers and non-users of tobacco or alcohol.
• Not pregnant or breastfeeding.
• Not receiving medications known to affect periodontal healing.
• Willing and able to provide written informed consent and comply with study procedures.

You may not qualify if:

• Pregnancy or breastfeeding.
• Presence of systemic diseases or medical conditions affecting periodontal status or healing.
• Current use of medications that may influence periodontal healing.
• Current smokers or users of tobacco or alcohol.
• Individuals unwilling or unable to provide informed consent.

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Ataturk University Faculty of Dentistry, Department of Periodontology

Erzurum, Erzurum, 25040, Turkey (Türkiye)

Location

Related Publications (2)

• Chung WC, Huang CF, Feng SW. Clinical Benefits of Minimally Invasive Non-Surgical Periodontal Therapy as an Alternative of Conventional Non-Surgical Periodontal Therapy-A Pilot Study. Int J Environ Res Public Health. 2022 Jun 17;19(12):7456. doi: 10.3390/ijerph19127456.

  PMID: 35742702 BACKGROUND

• Kucic AC, Gaspersic R. Minimally invasive non-surgical therapy (MINST) in stage III periodontitis patients: 6-month results of a split-mouth, randomised controlled clinical trial. Clin Oral Investig. 2023 May;27(5):2075-2087. doi: 10.1007/s00784-023-04994-4. Epub 2023 Apr 4.

  PMID: 37014505 BACKGROUND

MeSH Terms

Conditions

Periodontitis

Interventions

Root Planing

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dental Scaling; Dental Prophylaxis; Periodontics; Dentistry; Subgingival Curettage; Preventive Dentistry

Central Study Contacts

Alparslan Dilsiz, Professor, DDS, PhD

CONTACT

05334760078; aydilsiz@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Periodontology

Model Details: This is a randomized split-mouth clinical trial in which bilateral molar teeth within the same participant are randomly assigned to either the test or control intervention, allowing each participant to serve as their own control.

Study Record Dates

• First Submitted: August 5, 2026
• First Posted: August 10, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: August 10, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)