Effect of Tranexamic Acid on Bleeding After Bariatric Surgery

NCT07754396 | Completed

• 2 other identifiers: TXA-BARI-RETRO-202624049/28-07-2026
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative bleeding is an important complication of bariatric surgery and may lead to increased morbidity, prolonged hospitalization, and higher healthcare costs. Tranexamic acid (TXA) has been shown to reduce perioperative blood loss in several surgical specialties; however, evidence regarding its effectiveness and safety in bariatric surgery remains limited. This retrospective observational cohort study aims to evaluate the effect of prophylactic intraoperative tranexamic acid administration on perioperative bleeding in patients undergoing bariatric surgery. The primary objective is to assess the postoperative decrease in hemoglobin levels. Secondary objectives include evaluating the need for blood transfusion, length of hospital stay, and the incidence of thromboembolic complications, including deep vein thrombosis, pulmonary embolism, portal vein thrombosis, and acute coronary syndrome. The study includes patients who underwent bariatric surgery at G. Gennimatas General Hospital between May 1, 2024, and April 30, 2026.

Conditions

Perioperative Hemorrhage; Obesity; Tranexamic Acid; Postoperative Hemorrhage; Morbid Obesity

Keywords

Tranexamic Acid; TXA; Bariatric Surgery; Sleeve Gastrectomy; Blood Loss; Thromboembolism; Enhanced Recovery After Surgery; ERAS

Outcome Measures

Primary Outcomes (1)

• Postoperative Hemoglobin Reduction

  Difference between preoperative hemoglobin concentration and postoperative hemoglobin concentration following bariatric surgery, comparing patients who received prophylactic tranexamic acid with those who did not.

  48 hours after surgery

Secondary Outcomes (4)

• Blood Transfusion Requirement

  Up to 4 weeks

• 2. Length of Hospital Stay

  Up to 4 weeks

• Thromboembolic Complications

  Up to 4 weeks

• Postoperative Hemoglobin at 24 Hours

  24 hours after surgery

Study Arms (2)

Tranexamic Acid Group

Patients undergoing bariatric surgery who received prophylactic intraoperative tranexamic acid as part of routine clinical practice.

Control Group

No Tranexamic Acid Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing bariatric surgery at G. Gennimatas General Hospital between May 1, 2024, and April 30, 2026. Participants will be identified retrospectively from hospital medical records.

You may qualify if:

• Adults (≥18 years of age).
• Patients who underwent bariatric surgery at G. Gennimatas General Hospital between May 1, 2024, and April 30, 2026.
• Availability of complete perioperative and postoperative medical records.

You may not qualify if:

• Known thrombophilia.
• Coagulation disorders.
• Chronic anticoagulant or antiplatelet therapy.
• Previous pulmonary embolism.
• Coronary artery disease.
• Chronic kidney disease.
• Known hypersensitivity to tranexamic acid.

Sponsors & Collaborators

• G.Gennimatas General Hospital: lead

Study Sites (1)

General Hospital of Athens G. Gennimatas

Athens, Greece

Location

MeSH Terms

Conditions

Obesity, Morbid; Obesity; Postoperative Hemorrhage; Hemorrhage; Thromboembolism

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes; Postoperative Complications; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Amalia Douma, PHD

  General Hospital of Athens

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident anesthesiologist, Department of Anesthesiology, MSC in Clinical Pharmacology

Study Record Dates

• First Submitted: July 31, 2026
• First Posted: August 10, 2026
• Study Start: May 1, 2024
• Primary Completion: April 30, 2026
• Study Completion: April 30, 2026
• Last Updated: August 10, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)