The Role of Progesterone Membrane Receptors in the Development of Gestational Diabetes Mellitus

NCT07750431 | Active Not Recruiting DMC

• 2 other identifiers: 2025/313Samsun University
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the potential roles of PGRMC1, PGRMC2, and PAQR family membrane progesterone receptors in the pathophysiology of gestational diabetes mellitus by comparing their expression levels in placentas from pregnancies complicated by gestational diabetes mellitus with those from healthy pregnancies.

Conditions

Gestatiaonl Diabetes Mellitus

Keywords

gestational diabetes mellitus; progesterone membran receptors

Outcome Measures

Primary Outcomes (1)

• 1. Placental PGRMC1,PGRMC2 and PAQR mRNA expression levels

  Relative placental mRNA expression levels of PGRMC1, PGRMC2 and PAQR family receptors measured by quantitative real-time polymerase chain reaction (qRT-PCR) in placental tissue collected immedia

  Delivery

Study Arms (2)

Gestational diabetes mellitus group

Control Group

Gestational diabetes mellitus group and control group

Gestational diabetes mellitusGroupPregnant women diagnosed with gestational diabetes who will undergo placental tissue collection at delivery for molecularanalysis. Healthy Control GroupHealthy pregnant women with normal oral glucose tolerence test result who will undergo placental tissue collection at delivery for molecular analysis.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women aged 18-45 years delivering at Samsun City Hospital will be enrolled. The study population will consist of women with singleton pregnancies complicated by gestational diabetes mellitus and healthy pregnant women with appropriate fetal growth serving as the control group. Placental tissue samples will be collected immediately after delivery for molecular analysis.

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Samsun City Hospital

Samsun, Turkey (Türkiye)

Location

Related Publications (1)

• Arck P, Hansen PJ, Mulac Jericevic B, Piccinni MP, Szekeres-Bartho J. Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress. Am J Reprod Immunol. 2007 Sep;58(3):268-79. doi: 10.1111/j.1600-0897.2007.00512.x.

  PMID: 17681043 RESULT

MeSH Terms

Conditions

Diabetes, Gestational

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• SEMRA EROGLU

  Samsun University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 29, 2026
• First Posted: August 6, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: August 6, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL

Locations

TU (1)