Evaluation of Glycemic Impact on Fetal Liver Length and Volume by Ultrasound in Pregnancy

NCT07312838 | Not Yet Recruiting

• 1 other identifier: Fetal liver parameters by U/S
• Study Type: observational
• Target: 115
• Locations: 0 countries
• Sites: N/A

Brief Summary

The primary aim of this study is to evaluate whether fetal liver length and volume, as assessed by ultrasound, can serve as reliable markers of the metabolic impact of Gestational Diabetes Mellitus (GDM) on the fetus.

Conditions

FETAL LİVER VOLUME; Gestatiaonl Diabetes Mellitus

Keywords

Ultrasound; Fetal liver length; Fetal liver volume; Gestational diabetes mellitus

Outcome Measures

Primary Outcomes (4)

• Correlation of fetal liver length with maternal glycemic state

  Correlation of fetal liver length with maternal glycemic state

  12 weeks

• Comparison of fetal liver length

  Comparison of fetal liver length between women with gestational diabetes mellitus (GDM) and normoglycemic pregnancies.

  12 weeks

• Correlation of fetal liver volume with maternal glycemic state

  Correlation of fetal liver volume with maternal glycemic state

  12 weeks

• Comparison of fetal liver volume between women with gestational diabetes mellitus (GDM) and normoglycemic pregnancies.

  Comparison of fetal liver volume between women with gestational diabetes mellitus (GDM) and normoglycemic pregnancies.

  12 weeks

Secondary Outcomes (4)

• Correlation of fetal liver size with standard fetal biometry

  12 weeks

• Relationship of fetal liver measurements with neonatal outcomes

  12 weeks

• Comparison of abdominal circumference with fetal liver volume

  12 weeks

• Comparison of abdominal circumference with fetal liver length

  12 weeks

Eligibility Criteria

• Age: 18 Years - 52 Years
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Deep learning machine This prospective cohort consisted of pregnant women recruited from the antenatal clinics and fetal-medicine unit at Women's Health Hospital at Assiut University , between \[December 2025 - March 2029\]. Participants were enrolled at the time of their routine mid-trimester/anomaly ultrasound (targeted recruitment window 24weeks gestation for mid-trimester measures, with repeat/late scans at 36 weeks when required for longitudinal liver volume assessment)

You may qualify if:

• gestational age 24wks-36wks by an early pregnancy ultrasound exam including CRL length
• normal maternal blood sugar levels in early pregnancy
• diagnosed as GDM
• singleton viable pregnancy
• agree to include in study

You may not qualify if:

• preexisting diabetes
• fetal congenital anomalies or chromosomal abnormalities
• maternal chronic illnesses (e.g. Hypertension , thyroid disorders)
• multiple pregnancies

Sponsors & Collaborators

• Assiut University: lead

Related Links

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MeSH Terms

Conditions

Diabetes, Gestational

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Central Study Contacts

Yousef Ahmed Mahmoud Ahmed, Master

CONTACT

+201150003203; yousef.17308818@med.aun.edu.eg

Mohamed Mahmoud Abd-Allah

CONTACT

01061056747; dr_mabdallah1988@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Weeks
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Yousef Ahmed Mahmoud Ahmed

Study Record Dates

• First Submitted: November 24, 2025
• First Posted: December 31, 2025
• Study Start: January 1, 2026
• Primary Completion (Estimated): March 28, 2028
• Study Completion (Estimated): March 28, 2028
• Last Updated: December 31, 2025

Record last verified: 2025-12