Comparison Between Ultrasound Guided Quadratus Lumborum Block and Erector Spinae Plane Block as an Analgesic Modality in Renal Transplant Donors

NCT07749040 | Active Not Recruiting DMC

• 1 other identifier: MD118/2024
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Open surgery remains one of the approaches used for those patients requiring partial or radical nephrectomy and is associated with a high incidence of intense immediate postoperative pain (Gupta et al., 2013; Bravi et al., 2019). Erector Spinae Plane block (ESPB) has grown as a standard analgesic approach for thoracic, abdominal, and extremities surgeries because of its speed, ease of execution, minimal risk of hypotension and safety for patients with coagulopathy. Although it is believed that the spinal neurons' ventral and dorsal rami are involved, the exact pathway is yet uncertain (Forero et al., 2016; Hamed et al., 2019).

Conditions

Renal Transplantation; Nerve Block

Keywords

Quadratus lumborum nerve block; Erector spinae nerve block

Outcome Measures

Primary Outcomes (2)

• Time to first postoperative analgesia (the time from recovery to the first given dose of pethidine).

  24 hours postoperative

• Time to first postoperative analgesia

  Time to first postoperative analgesia (the time from recovery to the first given dose of pethidine).

  24 hours postoperatively

Secondary Outcomes (1)

• VAS for pain (ranging from 0 to 10, where 0 no pain and 10 maximum pain) will be evaluated postoperatively

  24 hours postoperative

Study Arms (2)

Quadratus lumborum nerve block

ACTIVE COMPARATOR

QLB will be done for patients in the study group at the end of surgery , before recovery of the patient from anesthesia. All blocks will be performed by one anesthesiologist experienced in U/S block; the patient will be placed in the lateral decubitus position according to the selected site of surgical interven-tion. The low-frequency convex probe of Sonosite M Turbo ultrasonography (FUJIFILM Sonosite, Inc., 124 S. E. ABD ELLATIF AND S. M. ABDELNABY Bothell, WA, USA) will be positioned horizontally in the anterior axillary line halfway between the subcostal margin and iliac crest after sterilization of the skin and draping, to locate the triple abdominal muscle layers, then the probe will be relocated subsequently to the posterior axillary line until the quadratus lumborum muscle could be visualized with its attachment to the lateral edge of the transverse process of the L4 vertebral body, With the psoas major muscle places anteriorly, the erector spinae muscle posteriorly

Procedure: Renal transplantation

Erector spinae nerve block

ACTIVE COMPARATOR

• In ESPB group In the ESPB group the patient will be placed in the lateral decubitus position according to the selected site of surgical intervention. After sterilization and drapping of the skin of the upper back, counting down from seventh cervical vertebrae spine to identify the spine of the seventh thoracic vertebrae (T7). This will be related to the tip of the scapular spine. A high-frequency probe of Sonosite M Turbo ultrasonography (FUJIFILM sonosite, Inc., Bothell, WA, USA) will be placed across the T7 spine and the probe will be moved laterally to identify the trans-verse process of T7. Thereafter, the probe will be moved to a sagittal plane to visualize the erector spinae muscles lying underneath the trapezius muscle. A 22- gauge, 80 mm needle (Stimuplex D, B-Braun, Germany) will be inserted medially inplane relative to the ultrasound probe and directed towards the transverse process. Once the needle is underneath the anterior fascia of the erector spinae muscle, 1 ml

Procedure: Renal transplantation

Interventions

Renal transplantation PROCEDURE

Two types of nerve will be applied to assess pain after renal transplantation in donors

Erector spinae nerve block; Quadratus lumborum nerve block

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Be over age 21
• Be willing to commit to the pre-donation evaluation process, surgery and the burden of recovery.
• No psychological condition.
• Fulfilling criteria for renal donation

You may not qualify if:

• Are under age 21
• Denying participating in the study
• Not fulfilling criteria for renal donation

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ainshams university

Cairo, Egypt

Location

MeSH Terms

Interventions

Kidney Transplantation

Intervention Hierarchy (Ancestors)

Renal Replacement Therapy; Therapeutics; Organ Transplantation; Transplantation; Surgical Procedures, Operative; Urologic Surgical Procedures; Urogenital Surgical Procedures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2026
• First Posted: August 6, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: August 6, 2026

Record last verified: 2026-07

Locations

EG (1)