Radiological and Surgical Analysis of Frontal Recess Variations in Endoscopic Sinus Surgery

NCT07748806 | Completed DMC

• 1 other identifier: MSCAZASTENT0301024792025
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction The frontal recess is a narrow and anatomically variable region that forms the frontal sinus drainage pathway. Variations in its anatomy, particularly those related to the agger nasi cell and other frontal recess cells, can impair frontal sinus drainage and contribute to the development of frontal sinus disease. High-resolution computed tomography and endoscopic evaluation are essential for identifying these variations and planning endoscopic sinus surgery. A thorough understanding of frontal recess anatomy is crucial for achieving adequate frontal sinus drainage, improving surgical outcomes, and minimizing complications due to the close proximity of the orbit and skull base. The Study aim to evaluate the anatomical variations of the frontal recess using radiological and surgical assessment and determine their significance in the management of frontal sinus disorders during endoscopic sinus surgery.

Conditions

Frontal Sinusitis; Frontal Sinus Recess; Endoscopic Sinus Surgery

Outcome Measures

Primary Outcomes (2)

• Size distribution of Agar nasi cells

  Distribution of different sizes of agar nasi cells among the participants: small, medium, and large

  Baseline

• Prevalence of aggar nasi cell

  The frequency of presence of aggar nasi cells on one side, bilateral, or absent

  Baseline

Study Arms (1)

patients presneted with chronic frontal sinusitis refreactory to medical treatment

OTHER

Patients who fulfill the inclusion criteria will undergo endoscopic sinus surgery and a CT scan to detect the anatomical variation of the frontal sinus, frontal recess, and the correlation of this viarations on surgical easiness

Procedure: endosocpic sinus surgery

Interventions

endosocpic sinus surgery PROCEDURE

Endoscopic sinus surgery to drain the frontal sinus and detect how easy it will be during surgery and its relation to anatomical variations

patients presneted with chronic frontal sinusitis refreactory to medical treatment

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age : (20 -60 years old ).
• Sex: both males and females.
• Patients were selected from the otorhinolaryngology outpatient clinic of Al-Azhar University Hospital in Assiut in a consecutive manner.
• All patients were generally well and fit for surgery.

You may not qualify if:

• Patients with massive inflammatory disease of specific in
• infections (e.g., rhinoscleroma).
• Malignancy.
• Severe nasal trauma.
• Foreign body.
• Previous nasal surgery.
• Atrophic diseases or systemic diseases and patients not fit for surgery.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Alazhar university Hopital in Assiut

Asyut, Egypt

Location

MeSH Terms

Conditions

Frontal Sinusitis

Condition Hierarchy (Ancestors)

Sinusitis; Respiratory Tract Infections; Infections; Paranasal Sinus Diseases; Nose Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ENT Specialist

Study Record Dates

• First Submitted: July 29, 2026
• First Posted: August 6, 2026
• Study Start: September 1, 2025
• Primary Completion: July 1, 2026
• Study Completion: July 1, 2026
• Last Updated: August 6, 2026

Record last verified: 2025-09

Locations

EG (1)