Different Endoscopic Approaches for Sphenoid Sinus

NCT07702188 | Not Yet Recruiting

• 1 other identifier: sphenoid sinus approaches
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

• Identification of the most effective approach for different lesion types
• Correlation between approach and complication rates

Conditions

Sphenoid Sinus; Endoscopic Sinus Surgery

Outcome Measures

Primary Outcomes (2)

• To evaluate different endoscopic surgical approaches to the sphenoid sinus

  * Complete lesion removal measured by post operative imaging ct * Complications examples Csf leakage Optic nerve injury (measured by visual acuity) * Carotid artery injury(bleeding) * Infection(meningitis csf examination if suspected)

  6 months

• To evaluate different endoscopic surgical approaches to the sphenoid sinus regarding: * Completence of lesion removal. * Complications. - Csf leakage - Optic nerve injury

  complications rate (csf leakage , optic nerve injury, carotid artery injury) * Recurrence * Endoscopic patency of sphenoid osteum and synechia formation

  6 month

Study Arms (1)

endoscopic approaches for sphenoid sinus

EXPERIMENTAL

type I, sphenoid ostial dilation. type IIa, transnasal sphenoidotomy (sphenoidotomy without ethmoidectomy). type IIb, transethmoidal sphenoidotomy (sphenoidotomy with ethmoidectomy). type III, bilateral, common cavity sphenoidotomy, or "sphenoid drill-out;" type IV, transpterygoid approach, to expose the lateral sphenoid sinus recess. type V, sphenoid nasalization, completely removing the sphenoid sinus floor.

Procedure: endoscopic sinus surgery

Interventions

endoscopic sinus surgery PROCEDURE

Different approaches include: type I, sphenoid ostial dilation. type IIa, transnasal sphenoidotomy (sphenoidotomy without ethmoidectomy). type IIb, transethmoidal sphenoidotomy (sphenoidotomy with ethmoidectomy). type III, bilateral, common cavity sphenoidotomy, or "sphenoid drill-out;" type IV, transpterygoid approach, to expose the lateral sphenoid sinus recess. type V, sphenoid nasalization, completely removing the sphenoid sinus floor.

endoscopic approaches for sphenoid sinus

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with sinonasal lesions involving sphenid sinus with or without skull base extension.

You may not qualify if:

• Severe comorbidities contraindicating surgery
• malignant tumer extend beyond sphenoid sinus requiring open management

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University Hospital

Asyut, Egypt

Location

Related Publications (1)

• https://scholar.google.com/?hl=ar

  BACKGROUND

Related Links

• Castelnuovo, P., Pagella, F., Semino, L., De Bernardi, F., \& Delù, G. (2005). Endoscopic treatment of the isolated sphenoid sinus lesions. European Archives of Oto-Rhino-Laryngology and Head \& Neck, 262(2), 142-147.
• 3-Jang, J. Y., Kim, G. J., Kim, S. Y., Kim, M. S., Lee, D. K., Kwon, M., ... \& Cho, K. J. (2025). Guidelines for the treatment of laryngeal cancer from the Korean society of head and neck surgery. Clinical and experimental otorhinolaryngology, 18(2), 89-
• -Lawson, W., \& Reino, A. J. (1997). Isolated sphenoid sinus disease: an analysis of 132 cases. The Laryngoscope, 107(12), 1590-1595..

Study Officials

• mohamed modather, assistant professor

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Doaa Araby Mohamed, assistant lecturer

CONTACT

+201119015094; DoaaAraby9@aun.edu.eg

Ahmed elrahman mohamed azzam, lecturer

CONTACT

01099978990; ahmedazzam@aun.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant lecturer

Study Record Dates

• First Submitted: July 7, 2026
• First Posted: July 14, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): August 1, 2028
• Study Completion (Estimated): September 1, 2028
• Last Updated: July 14, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)