Impact of Antioxidant-rich Supplementation on Skin Carotenoids Status, Antioxidant Status and Cardiometabolic Health in Overweight and Obese Individuals

NCT07748468 | Not Yet Recruiting

• 2 other identifiers: S39NUS-IRB-2026-268
• Study Type: interventional
• Target: 83
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the effects of antioxidant-rich supplementation on skin carotenoid status, antioxidant status, and cardiometabolic health in overweight and obese individuals. The study may provide additional scientific evidence to support the further refinement of current dietary and nutritional recommendations.

Conditions

Antioxidant Status; Overweight , Obesity

Keywords

Overweight; Obese; Antioxidants; Long-term; Body composition; Cardiometabolic health; Skin carotenoid

Outcome Measures

Primary Outcomes (2)

• Change in Skin Carotenoid Score Measured by Prysm iO™ from Baseline to Week 12

  Skin carotenoid status will be assessed using the Prysm iO™ device. The device scans the participant's fingertip and provides a skin carotenoid score, also referred to as the Prysm Score. Results will be reported as the numerical Prysm Score. Higher scores indicate higher skin carotenoid levels.

  Week 0, 4, 8, 12

• Mean Change from Baseline in Blood Carotenoid Concentration

  Blood carotenoid concentration will be assessed using blood samples collected from participants. Results will be reported as the mean change from baseline in blood carotenoid concentration at Week 12. Higher concentrations indicate higher circulating carotenoid status.

  Week 0 and Week 12

Secondary Outcomes (8)

• Mean Change from Baseline in Total Antioxidant Capacity in Blood Samples

  Week 0 and Week 12

• Mean Change from Baseline in Fasting Blood Lipid and Lipoprotein Concentrations

  Week 0 and Week 12

• Mean Change from Baseline in Fasting Blood Glucose Concentration

  Week 0 and Week 12

• Mean Change from Baseline in Fasting Blood Insulin Concentration

  Week 0 and Week 12

• Mean Change from Baseline in Blood Biomarkers of Oxidative Stress: Malondialdehyde and 8-Isoprostane

  Week 0 and Week 12

Other Outcomes (1)

• Mean Change from Baseline in Blood Clock Gene-Related Markers

  Week 0 and Week 12

Study Arms (3)

Control

NO INTERVENTION

Maintained habitual diet without receving the intervention.

LifePak Elements Supplementation

EXPERIMENTAL

Consume the LifePak (Elements) every day for 12 weeks.

Dietary Supplement: Antioxidant-rich supplementation Element

LifePak Optimal Supplementation

EXPERIMENTAL

Consume the LifePak (Optimal) every day for 12 weeks.

Dietary Supplement: Antioxidant-rich supplementation Optimal

Interventions

Antioxidant-rich supplementation Element DIETARY_SUPPLEMENT

Maintained habitual diet with additionally taking LifePak Element for 12 weeks

LifePak Elements Supplementation

Antioxidant-rich supplementation Optimal DIETARY_SUPPLEMENT

Maintaining habitual diet with additionally taking LifePak Optimal for 12 weeks

LifePak Optimal Supplementation

Eligibility Criteria

• Age: 21 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Able to give informed consent (AMT score ≥ 8 for older adults \[65-70 years old\])
• Adults 21-70 years old
• English-literate
• Have venous access sufficient to allow for blood sampling as per the protocol
• No drastic change of diet for the past 1 year
• If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 3 years prior to starting the study

You may not qualify if:

• Weight change \> 3kg in the past 3 months
• Exercising vigorously over the past 3 months
• Taking medications or dietary supplements which may impact eye/skin health
• Taking lipid-lowering and blood pressure controlling medications less than 3 years
• Smoking
• Drinking more than 2 alcoholic drinks per day
• Pregnant, lactating, or planning pregnancy in the next 6 months

Sponsors & Collaborators

• National University of Singapore: lead
• Nu Skin Enterprises: collaborator

Study Sites (1)

NUS, Department of Food Science and Technology, 1 Science Drive 3, Block S13, #03-07, Singapore, 117550

Singapore, 117542, Singapore

Location

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jung Eun Kim, Ph.D., R.D.

  National University of Singapore, Department of Food Science and Technology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lingyin Yu, B.Sc.

CONTACT

(+65) 8942 1809; e1124962@u.nus.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 15, 2026
• First Posted: August 5, 2026
• Study Start: August 15, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: August 5, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)