Swap Anesthetic Versus Continuous Desflurane in Adults Undergoing Bariatric Surgery

NCT07748247 | Not Yet Recruiting Phase 4

• 1 other identifier: CD2026/002
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to continuous desflurane anesthesia with respect to extubation time in adults undergoing elective laparoscopic bariatric surgery. Secondary outcomes include time to achieve a Patient State Index (PSi) greater than 80, time to achieve an Aldrete score of at least 8, incidence of postoperative nausea and vomiting, post-anesthesia care unit length of stay, and desflurane-related costs.

Conditions

Obesity; Bariatric Surgery

Keywords

Desflurane; Sevoflurane; General Anesthesia; Bariatric Surgery; Extubation Time; Obesity; Laparoscopic Gastric Bypass; Randomized Trial; Non-Inferiority Trial; Patient State Index

Outcome Measures

Primary Outcomes (1)

• Extubation Time

  Time in seconds from discontinuation of inhaled anesthetic agents to removal of the endotracheal tube.

  Perioperative

Secondary Outcomes (5)

• Time to Achieve Patient State Index Greater Than 80

  Perioperative

• Postoperative Nausea and Vomiting

  Up to 24 hours after surgery

• Time to Achieve an Aldrete Score of at Least 8

  Up to 24 hours after surgery

• Time to Post-Anesthesia Care Unit Discharge Readiness

  Up to 24 hours after surgery

• Desflurane-Related Cost

  Periprocedural (during surgery)

Study Arms (2)

Continuous Desflurane

EXPERIMENTAL

Participants receive desflurane as the inhalational anesthetic throughout the entire elective laparoscopic bariatric surgery according to the study protocol.

Drug: Desflurane

Sevoflurane-Desflurane Swap

EXPERIMENTAL

Participants receive sevoflurane during most of the procedure and are switched to desflurane 30 minutes before the end of surgery according to the study protocol.

Drug: Sevoflurane-Desflurane

Interventions

Desflurane DRUG

Desflurane administered as the inhalational anesthetic throughout the surgical procedure.

Continuous Desflurane

Sevoflurane-Desflurane DRUG

Sevoflurane administered during the initial phase of surgery followed by desflurane beginning 30 minutes before surgical closure.

Sevoflurane-Desflurane Swap

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or older.
• Scheduled for elective laparoscopic gastric bypass surgery.
• Body mass index between 30 and 50 kg/m².
• American Society of Anesthesiologists physical status II or III.
• Able and willing to provide written informed consent.

You may not qualify if:

• Surgical procedure lasting less than 2 hours.
• Body mass index greater than 50 kg/m².
• Significant cardiac disease.
• Moderate or severe obstructive respiratory disease, including uncontrolled asthma or chronic obstructive pulmonary disease.
• Pregnancy or breastfeeding.
• Known allergy or contraindication to medications used during the intraoperative period.
• Personal or family history of malignant hyperthermia.
• Active illicit drug use or substance dependence.
• Advanced chronic kidney disease, defined as an estimated glomerular filtration rate below 60 mL/min.
• Myasthenia gravis or another neuromuscular junction disorder.
• Severe cognitive or psychiatric disorder.
• Refusal to participate or withdrawal of informed consent at any time.

Sponsors & Collaborators

• Clínica Dávila: lead

Study Sites (1)

Clínica Dávila

Santiago, Santiago Metropolitan, 8431657, Chile

Location

MeSH Terms

Conditions

Obesity

Interventions

Desflurane

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Ethyl Ethers; Ethers; Organic Chemicals; Methyl Ethers; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Hydrocarbons

Central Study Contacts

Magdalena Estefo, MD

CONTACT

+56 9 7986 5505; magdalenaestefo@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Participants and postoperative outcome assessors are blinded to treatment allocation. The anesthesiologist administering the intervention is not blinded because of the nature of the anesthetic techniques
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will be randomized in a 1:1 ratio to receive either continuous desflurane anesthesia or a sevoflurane-desflurane swap strategy during elective laparoscopic bariatric surgery.

Study Record Dates

• First Submitted: July 24, 2026
• First Posted: August 5, 2026
• Study Start: August 3, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: August 5, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

CL (1)