Improving Management of Recipients of Care With HIV Viremia to Optimize Viral Suppression in Zambia: A Process and Outcome Evaluation

NCT07747987 | Completed

• 2 other identifiers: HVL Evaluation 3848-2023GH002251-01-01
• Study Type: interventional
• Target: 548
• Locations: 1 country
• Sites: 1

Brief Summary

The Centre for Infectious Disease Research in Zambia (CIDRZ) as an implementing partner (IP) through its Centers for Disease Control and Prevention (CDC) and President's Emergency Plan for AIDS Relief (PEPFAR)-funded programs provides technical assistance to the Zambian Ministry of Health (MOH) to support the 95-95-95 HIV care cascade targets. Following the expansion of the DSD approach to cover non-established PLHIV, the MOH, with assistance from CIDRZ piloted the introduction of viremic clinics (VCs) as a DSD model in Lusaka to manage recipients of care (ROCs) with unsuppressed viral loads. In this paper, we describe and report on the programmatic performance and outcomes of VL testing at 6 and 12-months in PLHIV on first line ART in the VC model programme in Lusaka province as well as identify the patient and healthcare workers facilitators and barriers to improve viral suppression within the VCs.

Conditions

HIV - Human Immunodeficiency Virus

Keywords

High Viral Load

Outcome Measures

Primary Outcomes (1)

• Viral suppression

  Viral Load copies \< 1000 after 3 months off successful enhance adherence counselling in viremic clinic

  3 to 6 months

Study Arms (1)

Viremic clinic

OTHER

Recipients of care managed in viremic clinics are assigned clinician and health care providers to provide patient entered care and manage them closely to achieve viral suppression.

Other: additional support

Interventions

additional support OTHER

Assigned specific day for high viral load recipients of care with a team of Health care providers to provide additional support and manage patients.

Viremic clinic

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• RoCs will be included if they are aged 15 years and above ,
• Started first line ART before March 2020
• on ART at least 6 months of continuous ART treatment
• With complete medical records in smart care, HVL registers and enrolled with HVL RoCs and active
• RoCs in the qualitative evaluation clinics
• Aged \>15 years old
• having received EAC in the past 6 months.
• \- Health care workers involved in the care of those who are not virally suppressed (treatment supporters, EAC counselors, professional healthcare workers)

You may not qualify if:

• \- ROCs\< 15 years,

Sponsors & Collaborators

• Centre for Infectious Disease Research in Zambia: lead
• Centers for Disease Control and Prevention: collaborator

Study Sites (1)

CIDRZ

Lusaka, 10101, Zambia

Location

MeSH Terms

Conditions

Acquired Immunodeficiency Syndrome

Condition Hierarchy (Ancestors)

HIV Infections; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Slow Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Study Officials

• Micheal Herce, Medical Doctor, MPH

  Centre for Infectious Disease Research in Zambia

  PRINCIPAL INVESTIGATOR

• Izukanji Sikazwe, Medical Doctor

  Centre for Infectious Disease Research in Zambia

  PRINCIPAL INVESTIGATOR

• James Simpungwe, Medical Doctor

  CDC-Zambia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Evaluation of outcome for veridic clinic implemented in Lusaka

Study Record Dates

• First Submitted: March 24, 2025
• First Posted: August 5, 2026
• Study Start: April 1, 2023
• Primary Completion: September 30, 2023
• Study Completion: September 30, 2023
• Last Updated: August 5, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

ZA (1)