Perfusion Index and Spinal Hypotension in Day-Case Knee Arthroscopy

NCT07747441 | Not Yet Recruiting

• 1 other identifier: AEŞH-EK-2026-171
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to investigate the role of the baseline perfusion index (PI) in predicting spinal anesthesia-induced hypotension (SAIH) in ASA I-II patients undergoing day-case knee arthroscopy. Spinal anesthesia is a widely preferred technique for lower extremity surgeries, including knee arthroscopy. However, sympathetic blockade during spinal anesthesia frequently leads to significant hemodynamic instability, particularly hypotension, which can result in adverse perioperative outcomes. While age and baseline blood pressure are traditional risk factors, they often fail to accurately predict the onset of hypotension in healthy populations. The perfusion index (PI), a non-invasive parameter measured via pulse oximetry, reflects peripheral vascular tone and baseline sympathetic activity. An elevated baseline PI indicates baseline vasodilation and a higher susceptibility to sympathectomy, potentially offering an early and non-invasive prediction of SAIH before the hemodynamic collapse occurs. The primary outcome of the study is the incidence of spinal anesthesia-induced hypotension (defined as a mean arterial pressure \< 65 mmHg or a decrease in systolic blood pressure \> 25% from baseline). Secondary outcomes include the onset time of sensory block, and intraoperative ephedrine and fluid requirements.

Conditions

Hypotension; Spinal Anesthesia Induced Hypotension; Anesthesia, Spinal; Arthroscopy

Keywords

Perfusion Index; Spinal Anesthesia; Hypotension; Knee Arthroscopy

Outcome Measures

Primary Outcomes (1)

• Spinal anesthesia-induced hypotension

  Defined as a mean arterial pressure \< 65 mmHg or a decrease in systolic blood pressure \> 25% from baseline

  During the surgery

Secondary Outcomes (2)

• Investigation of Sensory Block Kinetics

  Periprocedural

• Vasopressor Consumption

  During the surgery

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with American Society of Anesthesiologists physical status I or II who are scheduled for elective knee arthroscopy under spinal anesthesia at Etlik City Hospital will be consecutively screened for participation.

You may qualify if:

• Between the ages of 18-65
• Having an ASA Score of I-II
• Including data collection of parts that underwent knee arthroscopy

You may not qualify if:

• Patients under 18 and over 65 years of age
• Patients with ASA Score III and above

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (1)

Ankara Etlik City Hospital

Ankara, Yenimahalle\Ankara, 06170, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hypotension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

İbrahim MD Topcu, MD

CONTACT

05437860316; ibrahimtpc78@gmail.com

Musa Ass. Prof Zengin, Ass. Prof

CONTACT

05071302750; musazengin@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 30, 2026
• First Posted: August 5, 2026
• Study Start (Estimated): August 12, 2026
• Primary Completion (Estimated): December 14, 2026
• Study Completion (Estimated): December 28, 2026
• Last Updated: August 5, 2026

Record last verified: 2026-08

Locations

TU (1)