Central Line-Associated Bloodstream Infection QI Project

NCT07746674 | Not Yet Recruiting

• 1 other identifier: QI-CLABSI
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates a daily electronic health record (EHR) alert designed to reduce unnecessary central venous catheter (CVC) use among hospitalized adults. The alert identifies patients with an active CVC and no documented indication, prompting the first-contact provider to document line necessity. The study compares alert and a secure chat intervention to usual care, with the goal of reducing unnecessary line days and related CLABSI risk.

Conditions

Central Line-associated Bloodstream Infection (CLABSI)

Outcome Measures

Primary Outcomes (1)

• Total number of central line days without a documented indication

  Up to Month 3

Secondary Outcomes (2)

• Number of femoral central lines in place for more than 2 days

  Up to Month 3

• Number of non-tunneled hemodialysis catheters without an active hemodialysis or continuous renal replacement therapy order

  Up to Month 3

Study Arms (2)

Usual Care

Adult inpatients meeting eligibility criteria.

Secure Chat + Alert Cohort

Adult inpatients meeting eligibility criteria whose provider receives a daily EHR OPA alert and additional secure chat communication.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult inpatients with an active central venous catheter for at least 24 hours who meet alert eligibility criteria during the study period

You may qualify if:

• Not hospice patient class
• Active central line for at least 24 hours

You may not qualify if:

• No active central line
• Central line present for less than 24 hours

Sponsors & Collaborators

• NYU Langone Health: lead

Study Sites (1)

NYU Langone Health

New York, New York, 10016, United States

Location

Study Officials

• Holly Krelle

  NYU Langone Health

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sarah Tsuruo

CONTACT

914-815-4079; Sarah.Tsuruo@nyulangone.org

Holly Krelle

CONTACT

347-200-1108; Holly.Krelle@nyulangone.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 31, 2026
• First Posted: August 5, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: August 5, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)