The Association Between Chlorhexidine Bathing and Central Line-Associated Infections in Medical Intensive Care Units

NCT05919966 | Completed

• 1 other identifier: 202302031RINC
• Study Type: observational
• Target: 6,930
• Locations: 1 country
• Sites: 1

Brief Summary

We conducted a retrospective observational cohort study assessing the relationship between regular bathing using 2% CHG wipes every other day and the occurrence of central line-associated infections (CLABSI) in patients within the medical intensive care unit (MICU).

Conditions

Central Line-associated Bloodstream Infection (CLABSI)

Outcome Measures

Primary Outcomes (2)

• central line-associated bloodstream infections

  the incidence rate of intensive care unit acquired central line-associated bloodstream infections

  Will be surveyed retrospectively through the study period (January 2017 to June 2022)

• multidrug-resistant organisms bacteremia

  the incidence of CLABSIs with blood cultures positive for multidrug-resistant organisms

  Will be surveyed retrospectively through the study period (January 2017 to June 2022)

Secondary Outcomes (4)

• ICU length of stay

  Will be surveyed retrospectively through the study period (January 2017 to June 2022)

• hospital length of stay

  Will be surveyed retrospectively through the study period (January 2017 to June 2022)

• ICU mortality

  Will be surveyed retrospectively through the study period (January 2017 to June 2022)

• hospital mortality

  Will be surveyed retrospectively through the study period (January 2017 to June 2022)

Study Arms (2)

chlorhexidine group

Patients were bathed one day involving the use of wipes soaked in a 2% chlorhexidine gluconate (CHG) solution and the next day using a towel soaked with water and soap during the MICU stays.

Other: Chlorhexidine bathing

usual care group

Patients were bathed with towels soaked in water and soap on a daily basis during the MICU stays.

Interventions

Chlorhexidine bathing OTHER

The procedure involved pouring an entire bottle (200ml) of 2% CHG solution (PBF Biotech, Taipei, Taiwan) onto a pre-packed set of eight single-use cotton wipes before each bathing session. A minimum of six wipes were required to thoroughly cover the entire body, including the bilateral upper and lower extremities, front and back of the trunk, perineum, and buttocks.

chlorhexidine group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Our study included all patients aged eighteen years and older who were admitted to the MICU between January 2017 and June 2022, without any exclusions based on specific disease characteristics.

You may qualify if:

• all patients who were admitted to the MICU between January 2017 and June 2022

You may not qualify if:

• patients aged under 18 years old

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

Study Officials

• Yi-Chen Lin

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 13, 2023
• First Posted: June 27, 2023
• Study Start: April 12, 2023
• Primary Completion: April 30, 2023
• Study Completion: May 30, 2023
• Last Updated: June 27, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)