A Clinical Trial to Evaluate the Effects of Naila's Collagen Marine Plus Food Supplement on Skin Hydration, Elasticity, Fine Lines and Wrinkles, and Hair and Nail Health

NCT07746076 | Not Yet Recruiting

• 1 other identifier: GULFB-52447
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail health over 12 weeks. Forty healthy adults aged 40-60 years with self-reported mature skin showing early signs of aging will take one sachet of the supplement daily and complete questionnaires at Baseline, Week 4, Week 8, and Week 12. Participants will also submit standardized facial and hair photographs at Baseline and Week 12 for evaluation by a board-certified dermatologist. The primary objectives are to assess changes in skin aging parameters and hair health. Secondary objectives include evaluation of nail health, hair shedding and density, participant-reported satisfaction, and product safety and tolerability.

Conditions

Skin Aging; Skin Hydration; Skin Elasticity; Fine Lines and Wrinkles; Hair Health; Nail Health

Outcome Measures

Primary Outcomes (8)

• Change in Self-Reported Skin Hydration

  Mean change from Baseline in self-reported skin hydration assessed via self-reported questionnaire

  Baseline to Week 12

• Change in Self-Reported Skin Elasticity

  Mean change from Baseline in self-reported skin elasticity assessed via self-reported questionnaire

  Baseline to Week 12

• Change in Self-Reported Skin Firmness

  Mean change from Baseline in self-reported skin firmness assessed via self-reported questionnaire

  Baseline to Week 12

• Change in Self-Reported Fine Lines and Wrinkles

  Mean change from Baseline in self-reported appearance of fine lines and wrinkles assessed via self-reported questionnaire

  Baseline to Week 12

• Change in Dermatologist-Graded Fine Line and Wrinkle Severity

  Mean change from Baseline in fine line and wrinkle severity assessed by dermatologist review of standardized facial photographs

  Baseline to Week 12

• Change in Dermatologist-Graded Skin Firmness

  Mean change from Baseline in skin firmness assessed by dermatologist review of standardized facial photographs

  Baseline to Week 12

• Change in Dermatologist-Graded Overall Skin Quality

  Mean change from Baseline in overall skin quality assessed by dermatologist review of standardized facial photographs

  Baseline to Week 12

• Change in Dermatologist-Graded Hair Parameters

  Mean change from Baseline in hair health parameters assessed by dermatologist review of standardized hair photographs

  Baseline to Week 12

Secondary Outcomes (8)

• Change in Self-Reported Nail Strength

  Baseline to Week 12

• Change in Self-Reported Nail Brittleness

  Baseline to Week 12

• Change in Self-Reported Nail Growth Rate

  Baseline to Week 12

• Change in Self-Reported Overall Nail Appearance

  Baseline to Week 12

• Change in Self-Reported Hair Shedding

  Baseline to Week 12

Study Arms (1)

Naila's Collagen Marine Plus Food Supplement

EXPERIMENTAL

Dietary Supplement: Naila's Collagen Marine Plus Food Supplement

Interventions

Naila's Collagen Marine Plus Food Supplement DIETARY_SUPPLEMENT

All 40 participants receive Naila's Collagen Marine Plus Food Supplement (one sachet daily, dissolved in approximately 200 mL of water, taken once daily in the morning) for 12 weeks.

Naila's Collagen Marine Plus Food Supplement

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults aged 40-60 years at the time of enrollment.
• Self-reported visible signs of skin aging, including at least one of the following: fine lines, wrinkles, reduced skin firmness or elasticity, or skin dryness.
• Self-reports hair shedding and a desire to improve hair health.
• Willing to take one sachet of the study product daily for 12 weeks as directed.
• Willing to avoid taking any other collagen-containing dietary supplements for the duration of the study.
• Willing to maintain current diet, skincare routine, sleep patterns, and physical activity levels for the duration of the trial.
• Willing and able to submit standardized facial and hair photographs at Baseline and Week 12.
• Has access to a smartphone or digital camera capable of producing photographs.
• Resides in the United States.
• Willing to follow the study protocol and complete all required questionnaires.

You may not qualify if:

• Known allergy or sensitivity to fish, marine-derived products, or any of the study product ingredients (marine collagen, hyaluronic acid, ascorbic acid, biotin).
• Previous diagnosis of a hair loss condition such as alopecia areata, androgenetic alopecia, or telogen effluvium.
• Currently taking any collagen-containing dietary supplements, or planning to start taking any collagen supplements in the next 12 weeks.
• Any current uncontrolled chronic medical condition that would prevent the participant from safely completing the study protocol.
• History of a diagnosed dermatological condition that significantly affects facial skin appearance (e.g., severe eczema, psoriasis, rosacea, or active acne) and could confound assessment of skin aging outcomes.
• Use of prescription retinoids, injectable dermal fillers, botulinum toxin, chemical peels, laser skin treatments, or other professional aesthetic procedures on the face within 3 months prior to enrollment or planned during the study period.
• Currently pregnant, breastfeeding, or planning to become pregnant during the study period.
• Currently participating in another research study or planning to participate in another study during this study's duration.

Sponsors & Collaborators

• Gulf Bird: lead
• Citruslabs: collaborator

MeSH Terms

Interventions

Dietary Supplements

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Central Study Contacts

Patrick Renner

CONTACT

4242450284; hello@citruslabs.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2026
• First Posted: August 4, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: August 4, 2026

Record last verified: 2026-08