VWCR to Improve Cardiovascular Health and Outcomes Among Cardiac Patients: A Multicenter Randomized Clinical Trial Protocol (Destination Cardiac Rehab Study)
Virtual World-based Cardiac Rehabilitation to Improve Cardiovascular Health and Outcomes Among Cardiac Patients: A Multicenter Randomized Clinical Trial Protocol (Destination Cardiac Rehab Study)
2 other identifiers
interventional
150
1 country
3
Brief Summary
The purpose of this research is to compare health outcomes and participation between a virtual world cardiac rehabilitation (Destination Cardiac Rehab) program and the standard of care Center-based Cardiac Rehabilitation program. Destination Cardiac Rehab, developed with input from patients with heart disease and their caregivers, is a 3-D, interactive program offering an affordable telehealth option for cardiac rehabilitation (cardiac rehab) that can be done from home or any place that you can access the Internet with a computer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Aug 2026
Typical duration for not_applicable
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 30, 2026
CompletedStudy Start
First participant enrolled
August 1, 2026
CompletedFirst Posted
Study publicly available on registry
August 4, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 1, 2028
August 4, 2026
July 1, 2026
2 years
July 30, 2026
July 30, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Change in LE8 composite score
Life's Essential 8 score is a composite cardiovascular health (CVH) score developed by the American Heart Association (AHA) to quantify and track an individual's heart- and brain-health based on eight key lifestyle behaviors and clinical health factors (healthy diet, physical activity, nicotine exposure, sleep health, body mass index, lipids, glucose and blood pressure). The score ranges from 0 to 100 points, with higher scores indicating better overall cardiovascular health. Interpretation of the composite score usually follows these general categories: 0-49: Low cardiovascular health 50-79: Moderate cardiovascular health 80-100: High (optimal) cardiovascular health
Baseline, 3 Months, 6 Months
Secondary Outcomes (3)
Number of CV-related hospital readmissions
3 Months, 6 Months
Number of Deaths
3 Months, 6 Months
Number of CV Deaths
3 Months, 6 Months
Study Arms (2)
Virtual World-based Cardiac Rehabilitation
EXPERIMENTALControl Arm
ACTIVE COMPARATORInterventions
* Weekly Virtual Cardiac Rehabilitation Session * Virtual Nurse Coaching Visit (frequency: weekly) * Virtual Exercise Physiologist Visit (frequency: weekly) * Self-Directed Exercise: 3 sessions per week
Participants will attend three in-person cardiac rehabilitation sessions per week, each including: * Supervised exercise under the guidance of an Exercise Physiologist * Educational components related to cardiac health and lifestyle
Eligibility Criteria
You may qualify if:
- Indication for CR according to Centers for Medicare \& Medicaid Services (CMS) guidelines:
- Myocardial infarction within the preceding 12 months
- Coronary artery bypass surgery
- Current stable angina (chest pain)
- Heart valve repair or replacement
- Percutaneous transluminal coronary angioplasty (PTCA) or coronary stenting
- Heart or heart-lung transplant
- Stable chronic heart failure
- Aged ≥18 years
- Basic Internet navigation skills
- Active email address
You may not qualify if:
- High risk patients according to the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) risk stratification103 given safety concern of unsupervised exercise:
- Sudden cardiac arrest survivor
- Receiving continuous inotropic support
- Presence of a mechanical circulatory support device
- Decompensated heart failure
- Symptomatic valvular heart disease
- Uncontrolled angina
- Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia)
- Pregnant (due to associated hormonal and weight changes)
- Non-English-speaking
- Visual/hearing impairment or mental disability that would preclude independent use of the VW platform
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
- National Library of Medicine (NLM)collaborator
Study Sites (3)
University of California
Irvine, California, 92697, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
LaPrincess Brewer, MD, MPH
Mayo Clinic
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
July 30, 2026
First Posted
August 4, 2026
Study Start
August 1, 2026
Primary Completion (Estimated)
August 1, 2028
Study Completion (Estimated)
August 1, 2028
Last Updated
August 4, 2026
Record last verified: 2026-07
Data Sharing
- IPD Sharing
- Will not share