COG+OT Telerehabilitation for Adults With Subjective Cognitive Complaints

NCT07743229 | Not Yet Recruiting DMC

• 1 other identifier: Pro00151173
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 2

Brief Summary

This pilot study will evaluate a comprehensive cognitive assessment approach and personalized neurocognitive telerehabilitation intervention for adults with subjective cognitive complaints (SCC). The study includes older adults with SCC and adults with Ehlers-Danlos Syndrome (EDS) and SCC. Participants will complete pre- and post-treatment assessments and receive a 6-week COG+OT telerehabilitation intervention that combines cognitive rehabilitation and occupational therapy strategies to support everyday functional cognition.

Conditions

Subjective Cognitive Complaints; Ehlers-Danlos Syndrome; Cognitive Dysfunction

Keywords

Subjective cognitive complaints; Brain fog; Functional cognition; Occupational therapy; Cognitive rehabilitation; Ehlers-Danlos Syndrome

Outcome Measures

Primary Outcomes (1)

• Change in Everyday Cognition Scale-II (ECog-II) Score

  Change in subjective cognition measured using the Everyday Cognition Scale-II (ECog-II), a self-report measure assessing perceived cognitive functioning across everyday activities, including memory, executive function, language, and attention.

  Pre-treatment to post-treatment, approximately 8 weeks

Secondary Outcomes (2)

• Retention Rate

  Through study completion, approximately 8 weeks

• Adherence Rate

  Through study completion, approximately 8 weeks

Study Arms (1)

Adults With Subjective Cognitive Complaints

EXPERIMENTAL

Community-dwelling adults aged 60 years or older or Adult with Elhers Danlos Syndrome with subjective cognitive complaints who receive the 6-week COG+OT telerehabilitation intervention and complete pre- and post-treatment cognitive and functional assessments.

Behavioral: COG+OT Telerehabilitation

Interventions

COG+OT Telerehabilitation BEHAVIORAL

COG+OT is a personalized telerehabilitation program that combines cognitive rehabilitation and occupational therapy. Cognitive rehabilitation sessions focus on strategies for attention, memory, organization, planning, problem solving, and executive function. Occupational therapy sessions use meaningful daily activities to support application and generalization of cognitive strategies in home- and community-based tasks. The intervention is delivered remotely over 6 weeks in 10 sessions lasting approximately 45 to 60 minutes each.

Adults With Subjective Cognitive Complaints

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Endorsement of subjective cognitive complaints as indicated by a score ≥4 on the Healthy Brain 9 (HB9)
• Community-dwelling adult aged 60 years or older, or adult aged 21 years or older with a diagnosis of Ehlers-Danlos Syndrome (EDS)
• English as the primary language
• Access to and ability to use a smartphone compatible with the NeuroUX platform
• Access to a device capable of supporting a telerehabilitation visit, such as a phone, tablet, or laptop, and a reliable Wi-Fi or cellular internet connection
• Able to participate in study assessment sessions as determined by the licensed, experienced telerehabilitation occupational therapist

You may not qualify if:

• Diagnosis of dementia or mild cognitive impairment
• Significant or unstable conditions or treatments for medical conditions that may impact cognition, such as traumatic brain injury or brain tumor
• Inability to engage in study-related procedures as determined by the study team

Sponsors & Collaborators

• Medical University of South Carolina: lead

Study Sites (2)

Medical University of South Carolina

Charleston, South Carolina, 29412, United States

Location

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Location

MeSH Terms

Conditions

Ehlers-Danlos Syndrome; Cognitive Dysfunction; Mental Fatigue

Condition Hierarchy (Ancestors)

Hemostatic Disorders; Vascular Diseases; Cardiovascular Diseases; Hemorrhagic Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Skin Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin Diseases, Genetic; Genetic Diseases, Inborn; Collagen Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Skin Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Fatigue; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavioral Symptoms; Behavior

Study Officials

• Michelle Woodbury, PhD, OTR/L

  Medical University of South Carolina

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Patricia Finetto, OTR/L

CONTACT

843-792-8533; piersonp@musc.edu

Michelle Woodbury, PhD, OTR/L

CONTACT

woodbuml@musc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Michelle Woodbury, PhD, OTR/L, FAOTA

Study Record Dates

• First Submitted: July 29, 2026
• First Posted: August 3, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): July 31, 2027
• Study Completion (Estimated): July 31, 2027
• Last Updated: September 21, 2026

Record last verified: 2026-07

Locations

US (2)