Stroke Volume Versus Inferior Vena Cava Collapsibility Index to Predict Postinduction Hypotension in Intestinal Obstruction

NCT07742904 | Not Yet Recruiting

• 1 other identifier: FMASU MD49/2025
• Study Type: observational
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow tract velocity time integral (LVOT-VTI) versus the inferior vena cava collapsibility index (IVC-CI) using transthoracic echocardiography. The assessment will be conducted in adult patients with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia.

Conditions

Post-induction Hypotension; Intestinal Obstruction

Keywords

Stroke Volume; Inferior Vena Cava Collapsibility Index; LVOT-VTI; Echocardiography; General Anesthesia

Outcome Measures

Primary Outcomes (1)

• Efficacy of SV versus IVC-CI as Predictors for Post-Induction Hypotension Efficacy of SV versus IVC-CI as Predictors for Post-Induction Hypotension

  Comparison of the effectiveness and diagnostic accuracy (AUC) of stroke volume (SV) measured via LVOT-VTI versus inferior vena cava collapsibility index (IVC-CI) measured via TTE in predicting post-induction hypotension. Comparison of the effectiveness and diagnostic accuracy (AUC) of stroke volume (SV) measured via LVOT-VTI versus inferior vena cava collapsibility index (IVC-CI) measured via TTE in predicting post-induction hypotension.

  Measured baseline pre-induction and compared immediately post-induction.

Secondary Outcomes (3)

• Incidence of Post-Induction Hypotension Incidence of Post-Induction Hypotension

  Within 3 minutes following induction of general anesthesia.

• Length of Hospital Stay Length of Hospital Stay

  From date of surgery until hospital discharge (up to 9 months).

• Time to Recovery from Post-Anesthesia Care Unit (PACU) Time to Recovery from Post-Anesthesia Care Unit (PACU)

  Intraoperative / immediate postoperative period until PACU discharge (up to 24 hours).

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed with intestinal obstruction scheduled for exploratory abdominal surgery under general anesthesia at Ain-Shams University Hospitals.

You may qualify if:

• Adult patients with intestinal bowel obstruction undergoing exploratory abdominal surgery under general anesthesia.
• Age 40 to 70 years old.
• Body Mass Index (BMI) = 18 to 25 kg/m2.
• American Society of Anesthesiologists (ASA) physical status grade I or II.

You may not qualify if:

• American Society of Anesthesiologists (ASA) physical status grade \>= III.
• Patients in whom the IVC cannot be visualized or patients with poor echogenicity.
• Patients with hemodynamic instability.
• Patients with vascular, respiratory, or cardiac diseases (e.g., cardiomyopathy, heart valve disease, arrhythmia, or bad exercise tolerance).
• Pregnant patients.
• Difficult airway or multiple intubatio

Sponsors & Collaborators

• Ain Shams University: lead

MeSH Terms

Conditions

Intestinal Obstruction

Condition Hierarchy (Ancestors)

Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Study Officials

• Mohamed H Shokeir, M.D., Ph.D.

  Ain Shams University

  STUDY CHAIR

Central Study Contacts

Noura A Kamal, M.Sc.

CONTACT

+201119774236; NouraAbdel-Monem@med.asu.edu.eg

Islam A Taher, M.D.

CONTACT

+201005629809

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 29, 2026
• First Posted: August 3, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: August 3, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share