The Effect of Preoperative Intravenous Fluid Bolus on Post-induction Hypotension in Elective Cystoscopies.
1 other identifier
interventional
100
1 country
1
Brief Summary
This study aims to determine whether a standardized, weight-based crystalloid fluid bolus administered preoperatively reduces the incidence of postinduction hypotension (PIH) in patients undergoing cystoscopy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_4
Started Jul 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 1, 2025
CompletedFirst Posted
Study publicly available on registry
May 22, 2025
CompletedStudy Start
First participant enrolled
July 14, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2026
ExpectedSeptember 18, 2025
May 1, 2025
11 months
May 1, 2025
September 17, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Incidence of Postinduction Hypotension
Number of patients that experience a decrease in mean arterial pressure (MAP) greater than 20% from the baseline MAP.
From the time patient enters the operating room to the end of surgery, assessed up to 24 hours.
Other Outcomes (2)
Inferior Vena Cava Size
From the time of consent to the beginning of surgery, assessed up to 24 hours.
Respiratory Variability
From the time of consent to the beginning of surgery, assessed up to 24 hours.
Study Arms (2)
No Treatment
NO INTERVENTIONPatients will receive an ultrasound scan on their heart to determine cardiac output before surgery, but no fluid bolus will be given.
Preoperative Fluid Bolus
EXPERIMENTALPatients will receive an ultrasound scan on their heart to determine cardiac output and will also receive a fluid bolus of Lactated Ringers before surgery.
Interventions
A bolus of Lactated Ringers (15mL/kg of ideal body weight) will be given to patients prior to anesthesia induction.
Eligibility Criteria
You may qualify if:
- Age ≥ 18 years old.
- Undergoing elective cystoscopy surgery as the primary procedure.
- Able to provide informed consent.
You may not qualify if:
- Emergency surgeries.
- Past history of amputations of any body part.
- Allergies or contraindications to any medications used in the protocol or lactated ringers.
- Systolic heart failure with LVEF \< 30% within the last year.
- Severely depressed RV function within the last year.
- Restrictive diastolic dysfunction within the last year.
- Currently pregnant.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital
Columbia, Missouri, 65212, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sagar Bansal, MD
University of Missouri-Columbia
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Anesthesiology
Study Record Dates
First Submitted
May 1, 2025
First Posted
May 22, 2025
Study Start
July 14, 2025
Primary Completion
June 1, 2026
Study Completion (Estimated)
December 1, 2026
Last Updated
September 18, 2025
Record last verified: 2025-05