Acceleromyography Versus Electromyography for Neuromuscular Recovery Assessment at the End of Surgery

NCT07739862 | Not Yet Recruiting

• 1 other identifier: CD2026/16
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the agreement between acceleromyography and electromyography for measuring train-of-four (TOF) ratio at the end of surgery before reversal of neuromuscular blockade. Adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia with non-depolarizing neuromuscular blockade will undergo simultaneous TOF measurements using both monitoring methods. The study will assess the agreement between the two techniques, estimate measurement bias and limits of agreement, and determine the frequency of clinically relevant disagreement that could affect assessment of neuromuscular recovery and safe extubation.

Conditions

Neuromuscular Blockade; Cholecystectomy

Keywords

Acceleromyography; Electromyography; Train-of-Four; TOF Ratio; Neuromuscular Monitoring; Residual Neuromuscular Blockade; General Anesthesia; Laparoscopic Cholecystectomy; Bland-Altman Analysis; Diagnostic Agreement

Outcome Measures

Primary Outcomes (1)

• Agreement Between Acceleromyography and Electromyography Train-of-Four Ratios

  Agreement between the train-of-four (TOF) ratios measured simultaneously by acceleromyography and electromyography at the end of surgery. Agreement between the two measurement methods will be evaluated using Bland-Altman analysis.

  At the end of surgery, before administration of neuromuscular blockade reversal agents

Secondary Outcomes (4)

• Mean Bias Between Acceleromyography and Electromyography TOF Ratios

  At the end of surgery, before administration of neuromuscular blockade reversal agents

• Ninety-Five Percent Limits of Agreement Between TOF Monitoring Methods

  At the end of surgery, before administration of neuromuscular blockade reversal agents

• Proportional Bias Between Acceleromyography and Electromyography TOF Ratios

  At the end of surgery, before administration of neuromuscular blockade reversal agents

• Proportion of Participants With False Neuromuscular Recovery Indicated by Acceleromyography

  At the end of surgery, before administration of neuromuscular blockade reversal agents

Study Arms (1)

Adults Undergoing Elective Laparoscopic Cholecystectomy

Adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia with non-depolarizing neuromuscular blockade. Simultaneous train-of-four (TOF) ratio measurements will be obtained at the end of surgery using acceleromyography and electromyography before administration of neuromuscular blockade reversal agents.

Diagnostic Test: Simultaneous Acceleromyography and Electromyography Monitoring

Interventions

Simultaneous Acceleromyography and Electromyography Monitoring DIAGNOSTIC_TEST

Simultaneous quantitative neuromuscular monitoring using acceleromyography and electromyography to measure the train-of-four (TOF) ratio at the end of surgery before administration of neuromuscular blockade reversal agents.

Adults Undergoing Elective Laparoscopic Cholecystectomy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia with non-depolarizing neuromuscular blockade at Clínica Dávila.

You may qualify if:

• Adults aged 18 years or older.
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia.
• Administration of non-depolarizing neuromuscular blocking agents.
• Written informed consent provided.

You may not qualify if:

• Pre-existing neuromuscular disease.
• Upper extremity abnormalities preventing neuromuscular monitoring.
• Contraindications to neuromuscular monitoring.
• Refusal or inability to provide informed consent.

Sponsors & Collaborators

• Clínica Dávila: lead

Study Sites (1)

Clínica Dávila

Santiago, Santiago Metropolitan, 8431657, Chile

Location

MeSH Terms

Conditions

Delayed Emergence from Anesthesia

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Dagoberto Ojeda, MD

  Clínica Dávila

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 24, 2026
• First Posted: July 31, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: July 31, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

CL (1)