Radiological Diagnosis of Pediatric Neck Swellings

NCT07734805 | Active Not Recruiting

• 1 other identifier: Soh-Med-26-7-5MS
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Various diagnostic imaging modalities have been utilized in the assessment of pediatric neck lesions, including gray-scale and Doppler ultrasonography, conventional and three-dimensional computed tomography (CT), magnetic resonance imaging (MRI), and MR angiography, each offering distinct advantages and limitations.

Conditions

Lipoma; Branchial Cleft Anomalies; Cystic Hygroma (Macro-cystic Lymphatic Malformation); Rhabdomyosarcoma; Lymphadenitis; Neck Abscess; Myxoid Chondrosarcoma; Hemangiomas of Infancy; Thyroglossal Duct Cysts

Keywords

neck swellings; neck abscess; lymphadenitis; branchial cleft cyst; cervical lymphadenitis; nodal abscess; chondrosacroma; neck mass; hemangioma; thyroglossal duct cyst

Outcome Measures

Primary Outcomes (1)

• Diagnostic accuracy of tissue characterization of pediatric neck swellings

  Accuracy of multimodality imaging in characterizing pediatric neck swellings according to their imaging features and tissue composition, including cystic, solid, vascular, inflammatory, or other relevant characteristics, compared with the final diagnosis based on histopathological examination, microbiological assessment, surgical findings, or clinical and imaging follow-up, as applicable.

  From baseline imaging assessment until establishment of the final diagnosis, or up to 6 months after initial imaging, whichever comes first.

Other Outcomes (1)

• Sensitivity of multimodality imaging for diagnosis of pediatric neck swellings

  From baseline imaging assessment until establishment of the final diagnosis, or up to 6 months after initial imaging, whichever comes first.

Study Arms (1)

pediatric patients with neck swellings

Pediatric patients referred to Sohag University Hospital for radiological evaluation of a neck swelling or mass. Patients will undergo clinical assessment and appropriate imaging evaluation, including gray-scale and Doppler ultrasonography as the initial imaging modality, with CT and/or MRI performed when clinically indicated. Imaging findings will be assessed for lesion detection, anatomical localization, tissue characterization, differential diagnosis, and assessment of involvement of adjacent structures.

Eligibility Criteria

• Age: 1 Month - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients referred from pediatrics, ENT, surgery, oncology or emergency departments for radiological evaluation of a neck swelling/mass

You may qualify if:

• Pediatric patients referred from pediatrics, ENT, surgery, oncology or emergency departments for radiological evaluation of a neck swelling/mass

You may not qualify if:

• Previous surgery (post operative patients).
• Contraindications to intravenous contrast administration when contrast enhanced studies are required (e.g. history of severe contrast allergy).
• Contraindication to MRI (e.g., severe claustrophobia non-manageable by sedation).

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Faculty of Medicine Sohag University

Sohag, Sohag Governorate, 0000, Egypt

Location

MeSH Terms

Conditions

Lipoma; Branchial Cleft Anomalies; Lymphangioma, Cystic; Rhabdomyosarcoma; Lymphadenitis; Chondrosarcoma, Extraskeletal Myxoid; Thyroglossal Cyst; Branchioma; Hemangioma

Condition Hierarchy (Ancestors)

Neoplasms, Adipose Tissue; Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms; Lymphangioma; Neoplasm, Lymphatic Tissue; Myosarcoma; Neoplasms, Muscle Tissue; Sarcoma; Lymphatic Diseases; Hemic and Lymphatic Diseases; Cysts; Neoplasms, Vascular Tissue

Study Officials

• Mohamad Zaki Ali, MD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: July 24, 2026
• First Posted: July 29, 2026
• Study Start: February 20, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: July 30, 2026

Record last verified: 2026-07

Locations

EG (1)