The Effectiveness Of Home-Based Circuit Training On Eye Pressure And Eye Nerve Structures In Patients With Glaucoma

NCT07733388 | Not Yet Recruiting

• 1 other identifier: HBCT-GLAU-2026-01
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomised control trial is to learn about the effect of home based circuit training on patients with primary glaucoma. The main questions to answer are:

1. 1.Is there any difference of intraocular pressure (IOP) in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
2. 2.Is there any difference of retina nerve fibre layer in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?
3. 3.Is there any difference of choroidal thickness layer in patient with primary glaucoma after 6 weeks and 12 weeks who is performing home-based circuit training compared to patient not performing home-based circuit training?

Conditions

Glaucoma

Outcome Measures

Primary Outcomes (3)

• Intraocular pressure

  Baseline, at 6 weeks and at 12 weeks

• Retinal Nerve Fiber Layer

  Baseline, at 6 weeks and at 12 weeks

• Choroidal Thickness

  Baseline, at 6 weeks and at 12 weeks

Study Arms (2)

Home-Based Circuit Training

EXPERIMENTAL

Patients in Group A will be performing home-based circuit training three times per week for 12 weeks.

Behavioral: Home-Based Circuit Training

Control Group

NO INTERVENTION

Patients in Group B will not will be performing

Interventions

Home-Based Circuit Training BEHAVIORAL

Participants assigned to the intervention group will perform a home-based circuit training program in addition to receiving standard glaucoma care. The exercise program consists of seven home-based exercises, including two aerobic exercises and five resistance-based exercises performed in a circuit format. Each session will last 30 minutes for week 1-6 and 60 minutes for week 7-12. It is performed three times per week on alternate days for 12 weeks, and is conducted at moderate intensity. Participants will continue their prescribed glaucoma medications throughout the study.

Home-Based Circuit Training

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 - 70 years old
• Known case of POAG, PACG, JOAG, NTG
• Phakic without visually significant cataract
• Pseudophakic for more than 3 months prior to recruitment
• Achieved target IOP
• Physically not performing routine exercises

You may not qualify if:

• Bilateral eye visual acuity of less than 6/60
• Bilateral eye visual field defect of less than 10 degrees from fixation
• Patient with media opacities that affect the reliability of OCT measurements such as cornea opacity, dense cataract with Lens opacification classification system (LOCS III) of more than grade 2, vitreous haemorrhage
• Patient who underwent intraocular surgery (other than uncomplicated cataract surgery), including anti-vascular endothelial growth factor injection within past 6 months
• Ocular disease such as cornea ulcer, uveitis, age-related macula degeneration
• Physical disabilities such as stroke, limbs amputation
• Uncontrolled systemic diseases eg diabetes, hypertension
• Morbid Obesity (BMI \> 40)
• Dementia or any psychiatric diseases
• Smoking

Sponsors & Collaborators

• Universiti Sains Malaysia: lead

Study Sites (1)

Universiti Sains Malaysia

Kubang Kerian, Kelantan, 16150, Malaysia

Location

Related Publications (5)

• Zhu MM, Lai JSM, Choy BNK, Shum JWH, Lo ACY, Ng ALK, Chan JCH, So KF. Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health. Acta Ophthalmol. 2018 Sep;96(6):e676-e691. doi: 10.1111/aos.13661. Epub 2018 Jan 16.

  PMID: 29338126 RESULT

• Gonzalez-Devesa D, Suarez-Iglesias D, Diz JC, Esmerode-Iglesias A, Ayan C. Systematic review on the impact of exercise on intraocular pressure in glaucoma patients. Int Ophthalmol. 2024 Aug 19;44(1):351. doi: 10.1007/s10792-024-03216-4.

  PMID: 39160282 RESULT

• Anderson AJ. Exercise and Glaucoma: Positive Steps Toward Finding Another Modifiable Risk Factor to Prevent Vision Loss. Ophthalmology. 2019 Jul;126(7):965-966. doi: 10.1016/j.ophtha.2018.12.035. No abstract available.

  PMID: 31229007 RESULT

• Tribble JR, Hui F, Joe M, Bell K, Chrysostomou V, Crowston JG, Williams PA. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells. 2021 Feb 1;10(2):295. doi: 10.3390/cells10020295.

  PMID: 33535578 RESULT

• Gildea D, Doyle A, O'Connor J. The Effect of Exercise on Intraocular Pressure and Glaucoma. J Glaucoma. 2024 Jun 1;33(6):381-386. doi: 10.1097/IJG.0000000000002411. Epub 2024 May 10.

  PMID: 38722193 RESULT

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Central Study Contacts

THARANI ELUMALAI, MBBS

CONTACT

+60123789645; tharanicrystaline93@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 24, 2026
• First Posted: July 29, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: July 30, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

MY (1)