Evaluation of the Effects of Systemic Vibration Therapy on Thermogenesis, Cardiovascular Parameters, Endocrine-inflammatory Markers, and Physical-functional Performance in Adults With Obesity.

NCT07729215 | Completed

• 1 other identifier: 90160825.6.0000.5259
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial was to evaluate the effects of Systemic Vibration Therapy (SVT) on thermogenesis, cardiovascular health, endocrine-inflammatory markers, and physical performance in adults (men and women, aged 18-59) with obesity. The main questions it aimed to answer were: What were the effects of SVT on thermogenesis and physical-functional performance in people with obesity? How did SVT affect cardiovascular risk, hormone levels, and inflammation? Researchers compared two types of vibrating platforms (vertical and side-alternating) to a placebo group (where the platform was turned off but simulated the sound) to see if the vibration led to changes in these health parameters. Participants: Attended sessions 2 times per week for either 6 or 12 weeks. Stood barefoot in a static squat position on a vibrating platform for 29 minutes per session (alternating 1 minute of vibration with 1 minute of rest). Underwent health assessments, including blood tests, body composition scans, muscle strength tests, and quality of life questionnaires.

Conditions

Obese Adults

Keywords

whole-body vibration; systemic vibratory therapy; obesity; functionality; cardiovascular risk; muscle strength; body composition; adults; anthropometry

Outcome Measures

Primary Outcomes (2)

• Thermogenin

  Thermogenin (Uncoupling Protein 1 \[UCP1\]) was measured before and immediately after the WBV session. Blood samples were collected by a trained professional at the PPC/UERJ Clinical Analysis Laboratory (Capsule Unit), always during the same morning shift and no later than 8:00 a.m. For peripheral blood assays, serum and plasma collection tubes were centrifuged at 2,000 rpm at 25°C. Subsequently, 500 µL of serum was aliquoted into two microtubes and stored at -80°C until analysis. Serum UCP1 concentrations were determined using a specific enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's instructions. Optical density (OD) was measured using a Thermo Scientific spectrophotometer.

  Baseline, Week 6, and Week 12

• Endocrine-inflammatory profile

  The endocrine-inflammatory profile was assessed by measuring Interleukin-1 beta (IL-1β), Interleukin-1 Receptor Antagonist (IL-1RA), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), Tumor Necrosis Factor-alpha (TNF-α), Soluble TNF Receptor Type I (sTNF-RI), Soluble TNF Receptor Type II (sTNF-RII), adiponectin, resistin, leptin, and irisin. Blood samples were collected by a trained professional at the PPC/UERJ Clinical Analysis Laboratory (Capsule Unit), always during the same morning shift and no later than 8:00 a.m. For peripheral blood assays, serum and plasma collection tubes were centrifuged at 2,000 rpm at 25°C. Subsequently, 500 µL of serum was aliquoted into two microtubes and stored at -80°C until analysis. Biomarker concentrations were determined using specific enzyme-linked immunosorbent assay (ELISA) kits according to the manufacturer's instructions. Optical density (OD) was measured using a Thermo Scientific spectrophotometer.

  Baseline, Week 6, and Week 12

Secondary Outcomes (13)

• Total Body Water

  Baseline, Week 6, and Week 12

• Lean Body Mass, Fat Mass, and Skeletal Muscle Mass

  Baseline, Week 6, and Week 12.

• Body Fat Percentage

  Baseline, Week 6, and Week 12

• Basal Metabolic Rate

  Baseline, Week 6, and Week 12

• Body Mass Index (BMI)

  Baseline, Week 6, and Week 12

Study Arms (3)

Side-Alternating Vibratory Platform Group (SAVPG)

ACTIVE COMPARATOR

Systemic vibration therapy was performed on a vibrating platform with side-alternating displacement of the base, at a frequency of 30 Hz, with the peak-to-peak displacement adjusted to 2.5 mm or 5.0 mm. The individual was positioned barefoot, standing on the base of the vibrating platform, with the knees flexed at 50° (measured with a goniometer), in a static squat consisting of 1 minute of exposure to vibration followed by 1 minute of rest. This sequence was performed 15 times, totaling 29 minutes.

Device: Systemic vibratory therapy

Vertical Vibratory Platform Group (VVPG)

ACTIVE COMPARATOR

Systemic vibration therapy was performed on a vibrating platform with vertical displacement of the base, and the individual was positioned barefoot, standing on the base of the vibrating platform with the knees flexed at 50° (measured with a goniometer), at a frequency of 30 Hz, with the amplitude adjusted to "low." The participant was positioned in a static squat, consisting of 1 minute of exposure to mechanical vibration followed by 1 minute of rest. This sequence was performed 15 times, totaling 29 minutes.

Device: Systemic vibratory therapy

Control group (CG)

PLACEBO COMPARATOR

The individual was positioned barefoot, standing on the base of the side-alternating vibrating platform, with the knees flexed at 50° (measured with a goniometer). The vibrating platform was turned off and coupled with a device that simulated the sound of mechanical vibration. The volunteer performed the simulation in a static squat, consisting of 1 minute of exposure with the device turned on followed by 1 minute of rest with the device turned off. This sequence was performed 15 times, totaling 29 minutes.

Device: Systemic vibration therapy

Interventions

Systemic vibratory therapy DEVICE

The vertical displacement vibrating platform (Power Plate Pro 5, North America, Inc.) used features triplanar movement of its base (up and down, right and left, and forward and backward movements). However, the resultant of these movements is vertical; therefore, the individual felt as if it performed only the up and down movement while undergoing systemic vibration therapy. In this equipment, the frequency could be adjusted, and the amplitude was selected according to the chosen frequency, such as "high" or "low." The side-alternating displacement vibrating platform (KIKOS FITNESS, model P204IXC, São Paulo) that was used features base movements like a "seesaw," where the right side rises while the left side lowers and vice versa (in relation to the central fulcrum). On this equipment, the individual felt as if they were on a "seesaw." On this vibrating platform, the frequency could be adjusted, and the amplitude was selected according to the positioning of the individual's.

Also known as: vibrating platform

Side-Alternating Vibratory Platform Group (SAVPG); Vertical Vibratory Platform Group (VVPG)

Systemic vibration therapy DEVICE

The individual was positioned barefoot, standing on the base of the side-alternating vibrating platform. The vibrating platform was turned off and coupled with a device that simulated the sound of mechanical vibration.

Also known as: vibrating platform

Control group (CG)

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Individuals aged 18 to 59 years;
• Both sexes;
• Diagnosis of obesity, defined as a body mass index (BMI) ≥ 30 kg/m²;
• Waist-to-height ratio (≥ 0.50).

You may not qualify if:

• Presence of metallic prostheses;
• Presence of a pacemaker;
• Uncontrolled and untreated hypertension (≥180/120 mmHg);
• History of labyrinthitis;
• Previous diagnosis of deep vein thrombosis;
• Pregnancy;
• Recent surgery (within the previous 6 months);
• Neurodegenerative, pulmonary, or infectious diseases;
• Inability to undergo the proposed assessments and/or interventions.

Sponsors & Collaborators

• Laboratorio de Vibraçoes Mecanicas e Praticas Integrativas: lead
• Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.: collaborator
• Conselho Nacional de Desenvolvimento Científico e Tecnológico: collaborator
• Rio de Janeiro State University: collaborator
• Rio de Janeiro State Research Supporting Foundation (FAPERJ): collaborator

Study Sites (1)

Laboratório de Vibrações Mecânicas e Práticas Integrativas - Policlínica Universitária Piquet Carneiro

Rio de Janeiro, Rio de Janeiro, 20950-003, Brazil

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2026
• First Posted: July 27, 2026
• Study Start: October 31, 2024
• Primary Completion: January 31, 2026
• Study Completion: January 31, 2026
• Last Updated: July 27, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: Available indefinitely
• Access Criteria: Unending

Locations

BR (1)