ACCELERATE-CMR for Coronary Artery Disease Detection

NCT07729111 | Not Yet Recruiting DMC

• 2 other identifiers: 1151NIHR170057
• Study Type: interventional
• Target: 2,022
• Locations: 0 countries
• Sites: N/A

Brief Summary

Coronary heart disease occurs when the blood vessels that supply the heart become narrowed or blocked. It is a leading cause of illness and death in the UK. Accurate diagnosis is important because effective treatments are available, but current tests are invasive, uncomfortable, and carry some risks. Cardiovascular magnetic resonance (CMR), also known as a heart MRI scan, is a safe and accurate test for diagnosing coronary heart disease. However, access to CMR is limited because standard scans take around 45 to 50 minutes, restricting the number of patients who can be scanned. Researchers have developed a faster CMR scan that takes only 15 to 20 minutes. Previous studies suggest that this shorter scan provides similar accuracy to the standard scan while improving patient comfort. This study will recruit 2022 adults with suspected coronary heart disease from hospitals in the UK. Participants will be randomly assigned to receive either the standard CMR scan or the faster CMR scan. The study will compare whether the accelerated scan provides similar clinical outcomes to the standard scan and whether patients prefer it. If successful, the accelerated scan could increase access to CMR by allowing more patients to be scanned each day, and enabling more efficient use of NHS resources.

Conditions

CAD - Coronary Artery Disease

Keywords

MRI

Outcome Measures

Primary Outcomes (1)

• Composite clinical endpoint

  Composite of unnecessary invasive coronary angiography, unplanned coronary revascularisation, and additional non-invasive cardiac testing.

  12 months

Secondary Outcomes (12)

• Patient acceptability assessed using the MRI Scan Acceptability Theoretical Framework of Acceptability (TFA) Questionnaire

  Baseline (immediately following the MRI scan)

• Patient anxiety assessed using the MRI Scan Anxiety Questionnaire (MRI-AQ)

  Baseline (immediately following the MRI scan)

• Unnecessary invasive coronary angiography

  12 months, 24 months

• Unplanned coronary revascularisation

  12 months, 24 months

• Additional non-invasive cardiac testing

  12 months, 24 months

Study Arms (2)

Standard care arm stress CMR

ACTIVE COMPARATOR

Participants randomised to the standard care arm will undergo a standard stress cardiovascular magnetic resonance (CMR) scan

Procedure: Standard stress cardiovascular magnetic resonance (CMR)

Accelerated stress CMR

EXPERIMENTAL

Participants randomised to the accelerated arm will undergo an accelerated stress cardiovascular magnetic resonance (CMR) scan.

Procedure: Accelerated stress cardiovascular magnetic resonance (CMR)

Interventions

Standard stress cardiovascular magnetic resonance (CMR) PROCEDURE

Standard stress cardiovascular magnetic resonance (CMR) scan performed according to the study protocol.

Standard care arm stress CMR

Accelerated stress cardiovascular magnetic resonance (CMR) PROCEDURE

Accelerated stress cardiovascular magnetic resonance (CMR) scan performed according to the study protocol.

Accelerated stress CMR

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients \>18 years of age referred for routine clinical stress CMR:
• A) with chest pain or angina equivalent OR
• o B) with heart failure/suspected heart failure and referred for diagnosis of suspected CAD or evaluation of heart failure aetiology
• Willing and able to consent to participate in the trial

You may not qualify if:

• absolute contraindications to CMR (non-conditional cardiac implantable electronic devices, metallic implants/foreign bodies),
• contraindications to adenosine (severe pulmonary disease, sinus-node/high-grade atrioventricular disease)
• severe kidney dysfunction (estimated glomerular filtration rate \[eGFR\] \<30ml/min/1.73m2)
• uncontrolled arrhythmia or unstable chest pain
• severe claustrophobia
• previous invasive coronary angiography (within 12 months) with normal angiographic assessment and referred for CMR diagnosis of CMD

Sponsors & Collaborators

• University of Leicester: lead
• University of Glasgow: collaborator

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Ranjit Arnold

  University of Leicester

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fuad Fananapazir

CONTACT

+447763941607; accelerate@leicester.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Prospective, multi-centre, open-label randomised controlled trial with 1:1 randomisation of patients to standard/accelerated stress CMR

Study Record Dates

• First Submitted: July 8, 2026
• First Posted: July 27, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): September 1, 2029
• Study Completion (Estimated): May 1, 2031
• Last Updated: July 27, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share