Ultrasound-guided Combined Perineural and Intramuscular Dextrose Injection for Management of Refractory Bell's Palsy

NCT07728331 | Completed Phase 4 DMC

• 1 other identifier: 2023031799
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Bell's palsy (BP) is characterized by idiopathic acute weakness of the facial muscles associated with compression of the facial nerve. The present prospective study sought to evaluate the clinical efficacy of ultrasound-guided combined perineural and intramuscular dextrose injection for management of refractory Bell's palsy. The study included 30 patients with Bell's palsy with House-Brackmann scale ≥ 3 who were refractory to standard medical treatment after 3 months of disease onset. They received ultrasound-guided combined perineural and intramuscular dextrose injection. Clinical outcome was assessed using the House-Brackmann scale.

Conditions

Bell Palsy

Outcome Measures

Primary Outcomes (1)

• House Brackmann scale

  House Brackmann scale

  3 months

Study Arms (1)

Interventional arm

EXPERIMENTAL

Ultrasound-guided combined perineural and intramuscular dextrose injection.

Procedure: Ultrasound-guided combined perineural and intramuscular dextrose injection.

Interventions

Ultrasound-guided combined perineural and intramuscular dextrose injection. PROCEDURE

Ultrasound-guided combined perineural and intramuscular dextrose injection.

Interventional arm

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• \- The study included 30 patients with Bell's palsy diagnosed according to the recommendations of American Academy of Otolaryngology-Head and Neck Surgery Foundation

You may not qualify if:

• Patients were excluded if they were previously submitted to injection therapy or surgical intervention for management of Bell's palsy. They were also excluded if they had associated mental illness or advanced systemic conditions (e.g. uncontrolled diabetes, uncontrolled hypertension, malignant disease, immunocompromised conditions).

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Al-Azhar University Hospital

Cairo, 247883, Egypt

Location

MeSH Terms

Conditions

Bell Palsy

Condition Hierarchy (Ancestors)

Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Mouth Diseases; Stomatognathic Diseases; Facial Nerve Diseases; Cranial Nerve Diseases; Nervous System Diseases

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: July 22, 2026
• First Posted: July 27, 2026
• Study Start: October 10, 2025
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: July 27, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)