Evaluation of Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials

NCT07725029 | Completed

• 1 other identifier: MS.25.05.28
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the maxillary esthetic area. After atraumatic teeth extraction, immediate implant placement will be done and buccal jumping gap will be filled by demineralized dentin matrix in study group and control one by demineralized dentin matrix mixed with in injectable platelet rich fibrin.

Conditions

Tooth Extraction

Outcome Measures

Primary Outcomes (1)

• implant stability

  implant stability will be measured using Osstell mentor device

  12 months

Study Arms (2)

group 1

EXPERIMENTAL

buccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix for 16 cases

Other: Demineralized dentin matrix grafting material

group 2

EXPERIMENTAL

buccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin for 16 cases

Other: Demineralized dentin matrix with injectable platelet rich fibrin

Interventions

Demineralized dentin matrix with injectable platelet rich fibrin OTHER

After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin

group 2

Demineralized dentin matrix grafting material OTHER

After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix

group 1

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patient age ranged between 18-40 years old.
• Patients seeking to replace non-restorable tooth / teeth in maxillary esthetic zone (anterior \&premolars) by using immediate implant placement.
• Cooperative patients with high motivation and good oral hygiene.
• Intact socket wall after tooth extraction.
• Jumping gap more than 2mm.
• Favorable occlusion without presence of parafunctional habits, eg; bruxism and clenching.
• Sufficient inter-arch space to accommodate the future prothesis.
• Patients able to comply with the required recall visits.

You may not qualify if:

• Patients with known systemic diseases, which can affect normal bone formation or blood coagulation.
• Presence of signs of acute infection or pus formation.
• Pregnancy.
• Smoking.
• Patients on bisphosphonate drug.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura

Al Mansurah, Egypt

Location

MeSH Terms

Interventions

Demineralized Dentin Matrix

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor of oral and maxillofacial surgery

Study Record Dates

• First Submitted: July 21, 2026
• First Posted: July 24, 2026
• Study Start: June 1, 2025
• Primary Completion: September 1, 2025
• Study Completion: July 1, 2026
• Last Updated: July 24, 2026

Record last verified: 2026-07

Locations

EG (1)