Comparison of Combined (Superficial and Deep) and Isolated Deep Serratus Anterior Plane Blocks After Breast Surgery

NCT07724678 | Completed

• 1 other identifier: E.25/447
• Study Type: observational
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of this study is to compare the effectiveness of two different regional anesthesia techniques for pain management after oncological breast surgeries. The researchers will compare the combined (superficial and deep) serratus anterior plane block with the deep serratus anterior plane block. The study aims to evaluate which method provides better postoperative pain relief, reduces the total consumption of opioid analgesics, and improves patient comfort

Conditions

Breast Cancer; Postoperative Pain; Pain Management After Surgery

Keywords

Serratus Anterior Plane Block; Regional Anesthesia; Bupivacaine; Breast Surgery; Analgesia

Outcome Measures

Primary Outcomes (1)

• Visual Analog Scale (VAS) Scores for Postoperative Pain

  Assessment of postoperative pain using the Visual Analog Scale (VAS) (minimum score: 0, maximum score: 10, where higher scores indicate worse outcome).

  Postoperative 24 hours.

Secondary Outcomes (6)

• Total Tramadol Consumption

  Postoperative 24 hours.

• Need for rescue analgesia

  Postoperative 24 hours.

• Time to first rescue analgesia

  Postoperative 24 hours.

• Postoperative nausea and vomiting (PONV) scores

  Postoperative 24 hours.

• Patient satisfaction

  Postoperative 24 hours.

Study Arms (2)

Combined Serratus Anterior Plane Block Group

Patients receiving both superficial and deep serratus anterior plane block

Isolated Deep Serratus Anterior Plane Block Group

Patients receiving only deep serratus anterior plane block

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing elective modified radical mastectomy or breast-conserving surgery at SBU Ankara Egitim ve Arastirma Hastanesi

You may qualify if:

• Patients aged 18-80 years.
• Female patients with ASA physical status I, II, or III.
• Patients scheduled for elective modified radical mastectomy or breast-conserving surgery.
• Patients who provided written and verbal informed consent.

You may not qualify if:

• Patients with ASA physical status IV-V.
• Patients with a BMI ≥ 35 kg/m².
• Patients with chronic pain, opioid/substance addiction, or long-term analgesic use.
• Patients requiring emergency surgery.
• Pregnant patients.
• Known allergy to local anesthetics.
• Severe cardiovascular, cerebrovascular, liver, or renal disease.
• History of coagulopathy.
• Infection at the injection site or systemic infection.
• Patients who refuse the regional anesthesia technique, cannot speak the official language, or have mental disabilities/inability to cooperate.
• Patients with a history of previous breast surgery or those scheduled for bilateral operations.

Sponsors & Collaborators

• SBU Ankara Egitim ve Arastirma Hastanesi: lead

Study Sites (1)

Ankara Training and Research Hospital

Altındağ, Ankara, 00000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Breast Neoplasms; Pain, Postoperative; Agnosia

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Study Officials

• Meltem Bektas, Associate Professor

  SBU Ankara Egitim ve Arastirma Hastanesi

  STUDY DIRECTOR

• Dilara Hatice Arican, MD

  SBU Ankara Egitim ve Arastirma Hastanesi

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 17, 2026
• First Posted: July 24, 2026
• Study Start: April 21, 2025
• Primary Completion: January 28, 2026
• Study Completion: May 18, 2026
• Last Updated: July 24, 2026

Record last verified: 2026-07

Locations

TU (1)