VEXUS and Assessment of Dry Weight of Patients on Hemodialysis

NCT07721636 | Recruiting

• 1 other identifier: 0109628
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective, single-arm study that will be conducted over a period of 24 weeks. The same maintenance HD patients will be followed sequentially in two study phases, with each patient serving as their own control. The study aims to evaluate the role of POCUS, including LUS and VExUS score, in improving the assessment of volume status and determination of dry weight in patients undergoing maintenance HD. Phase I (Weeks 1-12): Clinical Assessment Phase During the first 12 weeks, all patients will be managed using standard clinical assessment alone. Determination of dry weight and calculation of target ultrafiltration (UF) will rely primarily on clinical parameters, including physical examination and routine clinical judgment. Phase II (Weeks 13-24): POCUS-guided assessment period During the second 12 weeks, the same patients will undergo POCUS assessment, including LUS and VExUS Score. LUS and VExUS examinations will be performed 30 minutes after the scheduled hemodialysis session. All measurements will be conducted during the mid-week dialysis session to reflect the average hydration status of each patient. At the end of each phase, the results of all patients will be correlated with assessment of dry weight by BIS (Inbody version 720). Inclusion criteria: ESRD patients on maintenance HD for more than three months. In the HD unit at Medical Research Institute and Faculty of Medicine. Alexandria University. Age: 25 -65 years old. The ability to give informed consent. Exclusion criteria:

• Patients with previous echocardiographic evidence of right heart dysfunction, tricuspid valve disease, or IVC thrombosis.
• Patients with liver cirrhosis
• Lung diseases: interstitial lung diseases, COPD patients.
• Obese (BMI≥30) Before inclusion in the study, all patients will be required to fill out a written informed consent. Also, approval from the Medical Ethics Committee will be obtained. Maintenance hemodialysis patients.

Conditions

Hemodialysis Patient; Dry Weight

Keywords

dry weight; POCUS; Hemodialysis; VExUS

Outcome Measures

Primary Outcomes (1)

• Change of patients dry weight between the two phases of the study

  Change of patient dry weight (in KG ) measured by bioimpedance device between the two phases of the study

  3 months

Study Arms (1)

Patients on maintenance hemodialysis

OTHER

the same patients will be used as their own control in two phase study where US will be used to determine patients dry weight

Diagnostic Test: ULTRASOUND for volume assessment

Interventions

ULTRASOUND for volume assessment DIAGNOSTIC_TEST

usage of US to determine patient dry weight and ultrafiltration volume needed

Also known as: POCUS, VEXUS, lung US

Patients on maintenance hemodialysis

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ESRD patients on maintenance HD for more than three months.
• In the HD unit at the Medical Research Institute and Faculty of Medicine. Alexandria University.
• Age: 25 -65 years old.
• The ability to give informed consent.

You may not qualify if:

• Patients with previous echocardiographic evidence of right heart dysfunction, tricuspid valve disease, or IVC thrombosis.
• Patients with liver cirrhosis
• Lung diseases: interstitial lung diseases, COPD patients.
• Obese (BMI≥30)

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Alexandria University Hospitals

Alexandria, Egypt

RECRUITING

MeSH Terms

Interventions

Ultrasonography

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor of internal medicine

Study Record Dates

• First Submitted: July 12, 2026
• First Posted: July 23, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): February 28, 2027
• Last Updated: July 23, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)