Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients

NCT07719712 | Recruiting

• 2 other identifiers: 2436 / 2424BAKIRCAY-2025-2424
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality of life. Identifying patients who are more likely to develop postoperative cognitive dysfunction or delirium remains a practical challenge in daily clinical practice. Better recognition of these patients may help tailor perioperative care and improve outcomes. This prospective observational study aims to identify perioperative factors associated with POCD and delirium in elderly patients undergoing transurethral resection and to develop a clinically applicable risk prediction model. Cognitive function and delirium are assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM). Cognitive function and delirium will be evaluated using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM). The results of this study may support clinicians in recognizing vulnerable patients earlier and may contribute to more individualized perioperative management.

Conditions

Postoperative Delirium; Postoperative Cognitive Dysfunction; Cognitive Dysfunction

Keywords

Postoperative Cognitive Dysfunction; Delirium; Transurethral Resection

Outcome Measures

Primary Outcomes (1)

• Incidence of postoperative cognitive dysfunction and delirium

  Postoperative cognitive dysfunction and delirium assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM). POCD is defined as a decline in MoCA score compared with baseline, and delirium is identified based on CAM criteria.

  Baseline (preoperative) and postoperative days 1, 2, and 3

Secondary Outcomes (2)

• Risk factors associated with POCD and delirium

  From baseline (preoperative) through postoperative day 3

• Performance of the predictive risk model

  Through study completion (anticipated November 2026)

Interventions

Cognitive and Delirium Assessment (MoCA and CAM) DIAGNOSTIC_TEST

Patients aged 65 years and older undergoing transurethral resection who are followed for the development of postoperative cognitive dysfunction and delirium.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital. These patients represent an elderly surgical population at risk for postoperative cognitive dysfunction and delirium. Participants are enrolled consecutively according to eligibility criteria and followed throughout the perioperative period.

You may qualify if:

• Age ≥65 years
• Scheduled for transurethral resection procedure
• ASA physical status I-III
• Able to provide informed consent
• Adequate cognitive function to complete preoperative assessment

You may not qualify if:

• Pre-existing diagnosis of dementia or severe cognitive impairment (MoCA \<18)
• Severe visual or hearing impairment preventing cognitive assessment
• History of psychiatric disease requiring antipsychotic or sedative medication
• Neurological disorders associated with increased delirium risk (e.g., Parkinson's disease, epilepsy)
• Inability to complete study assessments

Sponsors & Collaborators

• Muğla Sıtkı Koçman University: lead

Study Sites (1)

Muğla Training and Research Hospital

Muğla, 48000, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Emergence Delirium; Postoperative Cognitive Complications; Cognitive Dysfunction; Delirium

Condition Hierarchy (Ancestors)

Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Cognition Disorders

Study Officials

• Eylem Yasar, MD

  Mugla Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Eylem Yasar, MD

CONTACT

+905332392622; eylemtarakci@gmail.com

Melike Korkmaz Toker, MD

CONTACT

+905054747098; meltoker@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist

Study Record Dates

• First Submitted: July 13, 2026
• First Posted: July 22, 2026
• Study Start: April 5, 2026
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): November 15, 2026
• Last Updated: July 22, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)