Greek Validation of ACE III Test in Perioperative Patients

NCT04312516 | Completed

• 1 other identifier: ACEIIIPREOP
• Study Type: observational
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative neurocognitive disorders, including postoperative delirium (POD) and postoperaive cognitive dysfunction (POCD), are common complications of perioperative neurocognition in elderly patients undergoing surgery. POD and POCD have short- and long-term consequences, such as increased hospital stays and costs, augmented morbidity and mortality, as well as higher risk for cognitive decline later in life. Therefore, early prevention and diagnosis of these conditions is of great importance. A number of psychometric tests have been proposed as cognitive screening tools. Given the fact that many of them show weaknesses and difficulties in performance, scientists have sought for more useful alternatives. Montreal Cognitive Assessment (MoCA) is considered to be a good choice, as it has been successfully applied in the perioperative setting. What's more, it has been translated and validated for a Greek population with neurological disorders. Addenbrooke's Congnitive Examination III (ACE III) has been introduced recently into clinical practice. It is an easy to perform and detailed test that covers several neurocognitive domains and has shown high sensitivity and specificity in clinical conditions, including dementia and Alzheimer's disease. Although current literature lacks data concerning its perioperative use, ACE III could prove useful for screening patients undergoing surgery and anesthesia on the basis of its favorable characteristics as mentioned above. The aim of this study is to translate the ACE III (English version 2012) into Greek and assess its validity in perioperative patients aged \>55 years.

Conditions

Postoperative Delirium; Postoperative Cognitive Dysfunction

Keywords

ACE III; MoCA; Neurocognitive dysfunction; Perioperative

Outcome Measures

Primary Outcomes (2)

• Cultural adaption

  Cultural adaption of ACE III (English version 2012) into the Greek language

  2 months

• Validation

  Construct and convergent validity of the translated version of ACE III into the Greek language

  2 months

Study Arms (2)

Controls

Participants scheduled for surgery with MoCA score ≥ 26 preoperatively

Patients

Participants scheduled for surgery with MoCA score \< 26 preoperatively

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

128 surgical patients (cognitively and non-cognitively impaired)

You may qualify if:

• Patients scheduled for surgical intervention
• At least of primary level of education

You may not qualify if:

• Neurodegenerative disease
• Cerebrovascular disease
• Psychiatric disorders
• History of head injury
• Use of medication affecting the CNS

Sponsors & Collaborators

• Aristotle University Of Thessaloniki: lead

Study Sites (1)

AHEPA University Hospital

Thessaloniki, 54636, Greece

Location

MeSH Terms

Conditions

Emergence Delirium; Postoperative Cognitive Complications; Cognition Disorders

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Cognitive Dysfunction

Study Officials

• Maria Zouka, MD

  AHEPA University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant - Principal Investigator

Study Record Dates

• First Submitted: March 16, 2020
• First Posted: March 18, 2020
• Study Start: October 15, 2021
• Primary Completion: November 30, 2021
• Study Completion: December 18, 2022
• Last Updated: June 3, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)