Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care

NCT07719270 | Not Yet Recruiting

• 1 other identifier: ERB/14/204/AIMC/JHL
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The surgical removal of impacted lower wisdom teeth (mandibular third molars) frequently leads to uncomfortable postoperative symptoms, including pain, facial swelling (edema), and restricted jaw movement (trismus). This study aims to evaluate and compare the effectiveness of two different treatment strategies alongside standard care to reduce these complications. A total of 60 patients undergoing surgical extraction will be randomly assigned to one of three groups: Group A will receive a local submucosal injection of 10mg Triamcinolone (a corticosteroid), Group B will have Kinesiology Tape applied to the face to enhance fluid drainage, and Group C will receive standard postoperative care alone. Patient recovery outcomes, including pain levels, facial swelling, and jaw mobility, will be monitored and measured at 24 hours, 3 days, and 7 days after the surgery. The study's primary objective is to determine if adding either a pharmacological injection or a mechanical tape significantly improves patient recovery compared to standard postoperative care alone.

Conditions

Trismus; Edema; Pain

Keywords

Triamcinolone Acetonide; Kinesiology Taping; Third Molar Extraction; Maxillofacial Surgery

Outcome Measures

Primary Outcomes (1)

• Postoperative Pain Severity

  Postoperative pain severity will be assessed using a 10-point Visual Analog Scale (VAS), where 0 indicates "no pain" and 10 indicates "the worst pain imaginable

  Preoperatively (baseline), and at 24 hours, 3 days, and 7 days postoperatively

Secondary Outcomes (2)

• Postoperative Facial Swelling (Edema)

  Preoperatively (baseline), and at 24 hours, 3 days, and 7 days postoperatively

• Postoperative Trismus

  Preoperatively (baseline), and at 24 hours, 3 days, and 7 days postoperatively.

Study Arms (3)

Group A (Triamcinolone + Standard Care)

EXPERIMENTAL

Patients assigned to receive a single localized submucosal injection of 10mg Triamcinolone Acetonide immediately following surgical extraction of the lower third molar, alongside standard postoperative care.

Drug: Triamcinolone Acetonide 10mg; Other: Standard Postoperative Care

Group B (Kinesiology Taping + Standard Care)

EXPERIMENTAL

Patients assigned to receive application of facial Kinesiology Taping (KT) immediately post-surgery to assist with lymphatic drainage, alongside standard postoperative care.

Device: Kinesiology Taping; Other: Standard Postoperative Care

Group C (Standard Care Alone)

OTHER

Patients assigned to receive standard postoperative pharmacological care alone (such as prescribed oral analgesics and routine post-extraction instructions) with no additional localized intervention.

Other: Standard Postoperative Care

Interventions

Kinesiology Taping DEVICE

Elastic kinesiology tape applied over the masseteric region immediately after surgery to assist in tissue decompression and lymphatic flow.

Group B (Kinesiology Taping + Standard Care)

Standard Postoperative Care OTHER

Standard pharmacological regimen (routine oral analgesics/antibiotics) and post-operative home-care instructions.

Group A (Triamcinolone + Standard Care); Group B (Kinesiology Taping + Standard Care); Group C (Standard Care Alone)

Triamcinolone Acetonide 10mg DRUG

Single local submucosal injection of 10mg Triamcinolone Acetonide administered immediately after third molar surgical extraction.

Group A (Triamcinolone + Standard Care)

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-40 years
• Surgical patients requiring extraction of Impacted mandibular third molars

You may not qualify if:

• Known allergy to corticosteroids/adhesive
• Systemic diseases
• Active infection
• Pregnancy and lactation
• Surgical duration \> 45 minutes.

Sponsors & Collaborators

• Allama Iqbal Medical College: lead

Study Sites (1)

Allama Iqbal Medical College & Jinnah Hospital

Lahore, Punjab Province, 54590, Pakistan

Location

Related Publications (3)

• Wilkes MC, Scanlon V, Shibuya A, Cepika AM, Eskin A, Chen Z, Narla A, Glader B, Roncarolo MG, Nelson SF, Sakamoto KM. Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond-Blackfan anemia. Exp Hematol. 2022 Jul;111:66-78. doi: 10.1016/j.exphem.2022.04.005. Epub 2022 Apr 20.

  PMID: 35460833 RESULT

• Cavalcante DA, Gadelha A, Noto C. How challenging is to manage agitated patients? Braz J Psychiatry. 2019 Jul-Aug;41(4):277-278. doi: 10.1590/1516-4446-2019-4105. No abstract available.

  PMID: 31365715 RESULT

• Zerener T, Aydintug YS, Sencimen M, Bayar GR, Yazici M, Altug HA, Misir AF, Acikel C. Clinical comparison of submucosal injection of dexamethasone and triamcinolone acetonide on postoperative discomfort after third molar surgery. Quintessence Int. 2015 Apr;46(4):317-26. doi: 10.3290/j.qi.a33281.

  PMID: 25529005 RESULT

MeSH Terms

Conditions

Trismus; Edema; Pain

Interventions

Triamcinolone Acetonide

Condition Hierarchy (Ancestors)

Spasm; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Triamcinolone; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated

Study Officials

• Gulraiz Zulfiqar, BDS, FCPS OMFS, CHPE

  Allama Iqbal Medical College, Lahore

  STUDY CHAIR

Central Study Contacts

Kashaf Tariq, BDS, FCPS OMFS Resident

CONTACT

+923326043105; kashaftariq6242@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Three-arm, parallel-group, randomized controlled clinical trial

Study Record Dates

• First Submitted: July 18, 2026
• First Posted: July 22, 2026
• Study Start (Estimated): January 1, 2027
• Primary Completion (Estimated): June 1, 2028
• Study Completion (Estimated): January 1, 2029
• Last Updated: July 22, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)