NCT07719010

Brief Summary

The goal of this observational study was to evaluate the feasibility of percentage of velocity loss (%VL)-based approaches for prescribing training volume during constant-load and chain-based Smith machine back squats. The study aimed to answer whether %VL can be expressed as the maximum number of repetitions (%Rep) in constant-load and chain-based Smith machine squats. Twenty-six resistance-trained men performed repetitions-to-failure tests under variable (VRT) and constant resistance training (CRT). The %Rep attained before reaching different levels of effort were compared between VRT and CRT across various loads and sessions. Furthermore, this study evaluated the influence of different factors on the predictive accuracy of the %Rep-%VL relationships. These findings will provide evidence-based evidence in prescribing and monitoring intra-set volume.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
26

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Oct 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 7, 2025

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 10, 2026

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2026

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

July 15, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

July 22, 2026

Completed
Last Updated

July 22, 2026

Status Verified

July 1, 2026

Enrollment Period

3 months

First QC Date

July 15, 2026

Last Update Submit

July 18, 2026

Conditions

Keywords

level of effortlifting velocitytraining volumevelocity-based trainingvariable resistance training

Outcome Measures

Primary Outcomes (2)

  • The %Rep attained before reaching the 10%, 20%, and 30% VL thresholds

    The %Rep attained before reaching the 10%, 20%, and 30% VL thresholds was recorded across all loads, sessions, and loading configurations.

    April 1st, 2026

  • The %rep predictive accuracy

    To assess predictive accuracy, second-order polynomial regression equations were generated from the first session of each loading configuration using all repetitions within a set, setting %Rep as the dependent variable and %VL as the independent variable. These equations were constructed using different regression types (individual vs. general), load specificities (load-specific vs. multiple-load), and loading configurations (CRT vs. VRT). During the second session, the actual %VL recorded after reaching the 10%, 20%, and 30% VL thresholds was substituted into the corresponding first-session equations to derive the predicted %Rep. Then, the absolute estimation error was calculated as (\|actual %Rep - predicted %Rep\|). In cases where muscular failure occurred before a specific %VL threshold was reached (e.g., 30% VL), the %VL of the final completed repetition was recorded, and the corresponding actual %Rep was defined as 100%.

    April 1st, 2026

Interventions

Participants initially completed a standardized general warm-up and a specific warm-up. The specific warm-up protocol included 3 repetitions at approximately 40% 1RM, 2 repetitions at 65% 1RM, and 1 repetition at 90% 1RM using constant-load to ensure adequate neuromuscular activation for the subsequent testing sets. After a 3-minute rest, participants performed three sets to momentary muscular failure with 40% of total external loads provided by chains. To minimize fatigue from higher-repetition sets influencing the repetitions completed in subsequent loads, the loads were not tested in a randomized order. Instead, participants performed the tests in a descending order of 85%, 75%, and 65% 1RM.

Participants initially completed a standardized general warm-up and a specific warm-up. The specific warm-up protocol included 3 repetitions at approximately 40% 1RM, 2 repetitions at 65% 1RM, and 1 repetition at 90% 1RM using constant-load to ensure adequate neuromuscular activation for the subsequent testing sets. After a 3-minute rest, participants performed three sets to momentary muscular failure with 0% of total external loads provided by chains. To minimize fatigue from higher-repetition sets influencing the repetitions completed in subsequent loads, the loads were not tested in a randomized order. Instead, participants performed the tests in a descending order of 85%, 75%, and 65% 1RM.

Eligibility Criteria

Age18 Years+
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participant characteristics (mean ± standard deviation \[range\]) included: age, 20.4 ± 2.1 (18-25) years; body height, 1.78 ± 0.05 (1.68-1.87) m; body mass, 71.7 ± 7.5 (60.0-91.4) kg; training experience, 3.5 ± 1.8 (1-10) years; and constant-load 1RM, 135.4 ± 17.4 (95-163) kg, corresponding to 1.89 ± 0.21 (1.58-2.28) times body mass.

You may qualify if:

  • at least 1 year of resistance training experience, performing back squats at least once per week.
  • proficiency in the Smith machine back squat executed at maximal intended velocity.
  • a constant-load 1RM of ≥ 1.5 times their body mass.
  • no reported musculoskeletal injuries in the past three months.

You may not qualify if:

  • Voluntary withdrawal or injury.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Physical Education and Sports Science, South China normal university

Guangzhou, Guangdong, 510006, China

Location

Related Links

Study Design

Study Type
observational
Observational Model
CASE CROSSOVER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

July 15, 2026

First Posted

July 22, 2026

Study Start

October 7, 2025

Primary Completion

January 10, 2026

Study Completion

May 1, 2026

Last Updated

July 22, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will share

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
Individual participant data and supporting documents will become available after publication of the study results and will remain available for 5 years.
Access Criteria
Individual participant data (IPD) will be shared in anonymized form with qualified researchers for scientific purposes. The shared data will include lifting velocity of each repetition completed.

Locations