Impact of a Mobile Application-Based Medication Reminder on Treatment Adherence Among Patients With Chronic Diseases and Memory Impairment: A Nursing Leadership Perspective

NCT07718334 | Recruiting

• 1 other identifier: DFM-IRB 00012367- 26-04-001
• Study Type: interventional
• Target: 193
• Locations: 1 country
• Sites: 2

Brief Summary

This study aims to evaluate the impact of using a mobile application-based medication reminder on medication adherence among patients diagnosed with chronic diseases and memory impairment. Adherence to prescribed therapy is a significant challenge for this patient population, often leading to poor health outcomes and increased healthcare costs. From a nursing leadership perspective, innovative digital solutions can play a crucial role in supporting patient self-management. Using a quasi-experimental design, the study will investigate whether a customized mobile reminder system can effectively improve adherence rates and support patients in managing their therapeutic regimens.

Conditions

Chronic Disease; Memory Impairment

Keywords

medication adherence; mobile application; medication reminder; nursing leadership; quasi-experimental study

Outcome Measures

Primary Outcomes (1)

• Medication Adherence (MMAS-8)

  Medication adherence will be assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). This self-reported tool evaluates patients' behaviors regarding taking their prescribed chronic medications. Total scores range from 0 to 8, where a score of 8 indicates high adherence, 6 to \<8 indicates medium adherence, and \<6 indicates low adherence.

  Baseline (pre-intervention) and 3 months post-intervention

Secondary Outcomes (4)

• Objective Medication Adherence: Medication Possession Ratio (MPR)

  3 months post-intervention

• Objective Medication Adherence: Proportion of Days Covered (PDC)

  3 months post-intervention

• Cognitive Function Status (MMSE)

  Baseline

• Perceived Nursing Care and Leadership Support

  3 months post-intervention.

Study Arms (1)

Mobile Application Group

EXPERIMENTAL

Participants in this single-group study will receive training on and utilize a customized mobile application-based medication reminder designed to support adherence to their therapeutic regimens.

Device: Mobile Application-Based Medication Reminder

Interventions

Mobile Application-Based Medication Reminder DEVICE

The intervention consists of a mobile application specifically designed to support medication adherence. It features automated push notifications, customized reminder alerts matching prescribed medication schedules, and tracking logs. Participants will be instructed on how to install, configure, and use the application on their personal smartphones. The system is designed to provide immediate prompts to overcome memory-related adherence barriers.

Mobile Application Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients diagnosed with one or more chronic diseases requiring regular long-term medication.
• Patients exhibiting mild-to-moderate memory impairment or cognitive decline as screened by the Mini-Mental State Examination (MMSE).
• Patients who personally own and are capable of operating a smartphone or have a primary caregiver willing to manage the mobile application.
• Patients aged 18 years and older.
• Patients who provide voluntary informed consent to participate in the study.

You may not qualify if:

• Patients with severe cognitive impairment or advanced dementia who cannot interact with mobile technology even with caregiver assistance.
• Patients with severe acute clinical complications or unstable psychiatric conditions.
• Patients participating in another concurrent clinical trial or study targeting medication adherence

Sponsors & Collaborators

• Mansoura University: lead
• Al-Azhar University: collaborator
• Delta University for Science and Technology: collaborator

Study Sites (2)

Outpatient Clinics, Delta University for Science and Technology

Gamasa, Dakahlia Governorate, Egypt

RECRUITING

Outpatient Clinics, Kafr El-Sheikh Hospital

Kafr ash Shaykh, Kafr el-Sheikh Governorate, Egypt

RECRUITING

MeSH Terms

Conditions

Chronic Disease; Memory Disorders; Medication Adherence

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Central Study Contacts

Asmaa Elwan Hassan, PhD

CONTACT

+201063776424; asmaaelwan@mans.edu.eg

Mona Ahmed Gabr, PhD

CONTACT

201097898593

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Nursing Administration, Faculty of Nursing, Mansoura University, Egypt

Study Record Dates

• First Submitted: July 14, 2026
• First Posted: July 21, 2026
• Study Start: May 10, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: July 21, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (2)