Study of the Biomechanical and Histological Properties of Septal, Auricular, and Costal Cartilage in the Context of Optimizing Total Nasal Reconstruction

NCT07717138 | Not Yet Recruiting

• 1 other identifier: CHRD 0126
• Study Type: observational
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to understand the biomechanical properties of septal cartilage as well as the cartilages used in nasal reconstruction and to identify them histologically.

Conditions

Septoplasty; Rhinoseptoplasty; Rib Grafting; Otoplasty

Keywords

Septoplasty; Rhinoseptoplasty; Cartilage; Nasal; Otoplasty; Rib grafting

Outcome Measures

Primary Outcomes (1)

• Structural Histological Features of Septal, Costal, and Auricular Cartilage

  Structural analysis of cartilage architecture (e.g., chondrocyte distribution/density, extracellular matrix organization, perichondrium integrity) performed ex vivo on surgical waste tissue samples by histological staining, compared across the three cartilage types. No measurement is performed on participants in vivo.

  Through study completion, an average of one year

Secondary Outcomes (2)

• Young's Modulus of Septal, Costal, and Auricular Cartilage

  Through study completion, an average of one year

• Young's Modulus of Cartilage by Type, Patient Age, and Sex

  Through study completion, an average of 1 year

Study Arms (1)

Patients

Analysis of the biomechanical properties of septal cartilage as well as the cartilages used in nasal reconstruction and their histological identification.

Other: Analysis of the biomechanical properties of septal cartilage as well as the cartilages used in nasal reconstruction and their histological identification.

Interventions

Analysis of the biomechanical properties of septal cartilage as well as the cartilages used in nasal reconstruction and their histological identification. OTHER

Analysis of the biomechanical properties of septal cartilage as well as the cartilages used in nasal reconstruction and their histological identification.

Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who have undergone septoplasty, rhinoseptoplasty, or otoplasty, and in whom excess cartilage was removed during the surgical procedure. This cartilage, usually destined for disposal as surgical waste, is collected with the patient's consent, in accordance with current ethical and regulatory guidelines.

You may qualify if:

• Adult patients who have undergone septoplasty, rhinoseptoplasty, or otoplasty, and in whom excess cartilage was removed during the surgical procedure.
• This cartilage, usually destined for disposal as surgical waste, is collected with the patient's consent, in accordance with current ethical and regulatory guidelines.

You may not qualify if:

• Patient refusal

Sponsors & Collaborators

• Hôpital NOVO: lead

Study Sites (1)

Hopital NOVO

Pontoise, Île-de-France Region, 95300, France

Location

Related Publications (9)

• Griffin MF, Premakumar Y, Seifalian AM, Szarko M, Butler PE. Biomechanical characterisation of the human nasal cartilages; implications for tissue engineering. J Mater Sci Mater Med. 2016 Jan;27(1):11. doi: 10.1007/s10856-015-5619-8. Epub 2015 Dec 16.

  PMID: 26676857 BACKGROUND

• Griffin MF, Premakumar Y, Seifalian AM, Szarko M, Butler PE. Biomechanical Characterisation of the Human Auricular Cartilages; Implications for Tissue Engineering. Ann Biomed Eng. 2016 Dec;44(12):3460-3467. doi: 10.1007/s10439-016-1688-1. Epub 2016 Jul 14.

  PMID: 27417940 BACKGROUND

• Gunter JP, Clark CP, Friedman RM. Internal stabilization of autogenous rib cartilage grafts in rhinoplasty: a barrier to cartilage warping. Plast Reconstr Surg. 1997 Jul;100(1):161-9. doi: 10.1097/00006534-199707000-00026.

  PMID: 9207674 BACKGROUND

• Rotter N, Tobias G, Lebl M, Roy AK, Hansen MC, Vacanti CA, Bonassar LJ. Age-related changes in the composition and mechanical properties of human nasal cartilage. Arch Biochem Biophys. 2002 Jul 1;403(1):132-40. doi: 10.1016/S0003-9861(02)00263-1.

  PMID: 12061810 BACKGROUND

• Richmon JD, Sage AB, Wong VW, Chen AC, Pan C, Sah RL, Watson D. Tensile biomechanical properties of human nasal septal cartilage. Am J Rhinol. 2005 Nov-Dec;19(6):617-22.

  PMID: 16402652 BACKGROUND

• Richmon JD, Sage A, Wong WV, Chen AC, Sah RL, Watson D. Compressive biomechanical properties of human nasal septal cartilage. Am J Rhinol. 2006 Sep-Oct;20(5):496-501. doi: 10.2500/ajr.2006.20.2932.

  PMID: 17063745 BACKGROUND

• Westreich RW, Courtland HW, Nasser P, Jepsen K, Lawson W. Defining nasal cartilage elasticity: biomechanical testing of the tripod theory based on a cantilevered model. Arch Facial Plast Surg. 2007 Jul-Aug;9(4):264-70. doi: 10.1001/archfaci.9.4.264.

  PMID: 17638761 BACKGROUND

• Chang B, Reighard C, Flanagan C, Hollister S, Zopf D. Evaluation of human nasal cartilage nonlinear and rate dependent mechanical properties. J Biomech. 2020 Feb 13;100:109549. doi: 10.1016/j.jbiomech.2019.109549. Epub 2019 Nov 29.

  PMID: 31926590 BACKGROUND

• Brown WE, Lavernia L, Bielajew BJ, Hu JC, Athanasiou KA. Human nasal cartilage: Functional properties and structure-function relationships for the development of tissue engineering design criteria. Acta Biomater. 2023 Sep 15;168:113-124. doi: 10.1016/j.actbio.2023.07.011. Epub 2023 Jul 16.

  PMID: 37454708 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Cartilage

Study Officials

• Khaled AL TABAA

  Hôpital NOVO

  PRINCIPAL INVESTIGATOR

• Emmanuel PAUTHE

  CY Paris Université

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mathilde WLODARCZYK

CONTACT

0033130754650; mathilde.wlodarczyk@ght-novo.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2026
• First Posted: July 21, 2026
• Study Start: June 1, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: July 21, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)