Association Between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea

NCT07716995 | Not Yet Recruiting

• 1 other identifier: 04-2026-300909
• Study Type: observational
• Target: 127
• Locations: 0 countries
• Sites: N/A

Brief Summary

Association between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea

Conditions

Obstructive Sleep Apnea; Metabolic Dysfunction-Associated Steatotic Liver Disease

Outcome Measures

Primary Outcomes (1)

• Correlation Between Apnea-Hypopnea Index and MASLD

  To assess the correlation between the Apnea-Hypopnea Index (AHI), measured by overnight polysomnography (events/hour), and hepatic steatosis measured by FibroScan with Controlled Attenuation Parameter (CAP), reported in decibels per meter (dB/m).

  At baseline

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

* Patients with a clinical suspicion of sleep-disordered breathing will undergo overnight polysomnography and the followings indices will be recorded(apnea-hypopnea index (AHI); oxygen desaturation index (ODI); lowest arterial oxyhemoglobin saturation during sleep(LaSO2); mean arterial oxyhemoglobin saturation during sleep(mean SpO2); and %sleep time in which SpO2 \< 90%.( TS90%). * Diagnosis of MAFLD will made when a patient has BMI \>25 kg/m2, T2DM or at least two metabolic risk abnormalities. * All patients will undergo data pertaining to clinical history (name, age, sex, residence, occupation, co-morbidities… diabetes, hyperlipidemia, hypertension, ischemic heart disease, special habits; such as alcohol intake and smoking). * Four anthropometric measurements will be obtained (height, weight, body mass index, waist circumference (WC)). * Blood samples will be collected for doing liver function tests, lipid profile, CBC, HbA1c.

You may qualify if:

• Patients aged \>18 years old
• presented with a clinical suspicion of sleep-disordered breathing, including snoring, sleepiness and witnessed sleep apnea

You may not qualify if:

• Patients aged ≤18 years old
• Pregnancy
• Presence of malignancy
• Type I DM
• Patients with fatty liver who undergone bariatric surgeries.
• Patients with Central sleep apnea, upper airway resistance and narcolepsy
• Patients with lung diseases with hypoxia
• Previous history of alcohol consumption, steroids, proton pump inhibitors, antibiotics, and contraceptive pills

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Central Study Contacts

Amira Mohamed Abdelmawgod, MD, Assuit University

CONTACT

+201012760437; amiramohmad60@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Lecturer of Tropical Medicine and Gastroenterology

Study Record Dates

• First Submitted: July 14, 2026
• First Posted: July 21, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2027
• Last Updated: July 22, 2026

Record last verified: 2026-07