Magnetic Resonance Cholangiopancreatography in Living Liver Donors and Its Relationship With Post Operative Recipient Biliary Complications

NCT07715500 | Recruiting

• 1 other identifier: IEC/2025/119/MA04
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Living donor liver transplantation is widely accepted as an life-saving treatment for patients with end-stage liver diseases. Careful donor selection is essential to maximize the success and minimize the risk of postoperative complications in donors and recipients. Mapping of biliary anatomy is one of the critical assessments for donor selection and surgical planning ,Biliary reconstruction is considered as the "Achilles heel" of liver transplantation and adequate imaging assessment of biliary anatomy can largely benefit the biliary anastomosis. Preoperative imaging assessment of biliary anatomy is good for the selection of donors but may not indispensable for surgical planning and Intraoperative confirmative assessment of biliary anatomy with IOC was essential

Conditions

Chronic Liver Disease and Cirrhosis; Liver Transplant; Complications; Donor Hepatectomy

Keywords

Liver Transplantation; Magnetic Resonance Cholangiopancreatography; Liver donors

Outcome Measures

Primary Outcomes (1)

• To identify factors causing early biliary complications like type and number of arterial & biliary reconstruction, type of graft, number & size of Bile ducts in donor in both groups

  6 month of postop

Secondary Outcomes (2)

• Donor biliary complications in both group

  1 month of postoperative period

• Identify Risk factors for early Biliary complications in recipients

  till 6 months of Post operative period of Liver transplant

Study Arms (2)

No MRCP GROUP

NO INTERVENTION

Magnetic Resonance Cholangiopancreatography is not done as part of Routine Liver donor workup

MRCP GROUP

EXPERIMENTAL

Magnetic Resonance Cholangiopancreatography is done as part of Routine Liver donor workup

Diagnostic Test: Magnetic Resonance Cholangiopancreatography

Interventions

Magnetic Resonance Cholangiopancreatography DIAGNOSTIC_TEST

Magnetic Resonance Cholangiopancreatography is being excluded from list of Investigation as part of Non inferiority trial

MRCP GROUP

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• All prospective voluntary healthy liver donor of age 18-55

You may not qualify if:

• Type C/D Portal vein anatomy
• Left sided Gallbladder
• Right Posterior Graft
• Recipients undergoing Hepaticojejunostomy

Sponsors & Collaborators

• Institute of Liver and Biliary Sciences, India: lead

Study Sites (1)

ILBS

New Delhi, 110070, India

RECRUITING

MeSH Terms

Conditions

Fibrosis

Interventions

Cholangiopancreatography, Magnetic Resonance

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Magnetic Resonance Imaging; Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Digestive System

Central Study Contacts

Dr Atul Renjit, MBBS, MS, DNB

CONTACT

+91 9632060230; atulrenjit@gmail.com

Dr Nilesh Sadashiv Patil, MCH

CONTACT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 1, 2026
• First Posted: July 20, 2026
• Study Start: July 1, 2025
• Primary Completion: July 15, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: July 20, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)