Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography in Patients With Obstructive Jaundice

NCT06754397 | Not Yet Recruiting

• 1 other identifier: Soh-Med--24-12-04MS
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Evaluate the diagnostic accuracy of Magnetic Resonance Cholangiopancreatography (MRCP) compared with Ultrasound and Computed Tomography (CT) in patients with obstructive jaundice taking findings of ERCP/ PTC and histopathology as gold standard.

Conditions

Obstructive Jaundice

Outcome Measures

Primary Outcomes (1)

• Diagnostic accuracy of Magnetic Resonance Cholangiopancreatography in patients with obstructive jaundice according to the findings

  Magnetic Resonance Cholangiopancreatography findings in patients with obstructive jaundice comparing to findings of ERCP/ PTC and histopathology .

  Within twelve months

Study Arms (1)

Patients diagnosed with obstructive jaundice

MRCP as a role that is used as a non-invasive diagnostic tool for visualizing the pancreaticobiliary tree without the use of contrast media

Diagnostic Test: Magnetic Resonance Cholangiopancreatography

Interventions

Magnetic Resonance Cholangiopancreatography DIAGNOSTIC_TEST

Three most important sequences included axial T2 weighted scan from liver to ampullary region followed by T2 weighted 3D FSE sequence acquired in coronal oblique plane using respiratory triggering by tying bellows over abdomen. After this breath hold HASTE sequence is acquired in coronal plane. Maximum intensity projection (MIP) and thick slab images are also used for interpretation. US, CECT and MRCP scans are interpreted by radiologists blinded to other imaging findings

Also known as: Ultrasound, Computed tomography

Patients diagnosed with obstructive jaundice

Eligibility Criteria

• Age: 15 Years - 89 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult male and female patients clinically diagnosed obstructive jaundice are included in the study with positive laboratory tests.

You may qualify if:

• Adult male and female patients clinically diagnosed obstructive jaundice are included in the study with positive laboratory tests.

You may not qualify if:

• Patients with non-obstructive (prehepatic/hepatic) cause of jaundice. Patients having contraindications to perform MRI (Patients with any electrically, magnetically or mechanically activated implants, pacemaker, cochlear implants or any metallic orthopedic implants and claustrophobic patients).

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Jaundice, Obstructive

Interventions

Cholangiopancreatography, Magnetic Resonance; Ultrasonography; Tomography, X-Ray Computed

Condition Hierarchy (Ancestors)

Jaundice; Hyperbilirubinemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Skin Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Magnetic Resonance Imaging; Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Digestive System; Image Interpretation, Computer-Assisted; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray

Study Officials

• Magdy M Amin, Professor

  Medical research ethics committee - Sohag university

  STUDY DIRECTOR

Central Study Contacts

Demiana M Soliman, Resident

CONTACT

01211992362; r.demiana.mohsen@gmail.com

Hisham A Amin, A. professor

CONTACT

+20 115 115 2564

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Radiological resident

Study Record Dates

• First Submitted: December 22, 2024
• First Posted: December 31, 2024
• Study Start: January 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: December 31, 2024

Record last verified: 2024-12