Post-operative Cognitive Decline After Ambulatory Cataract Surgery in the Elderly Population

NCT07714174 | Not Yet Recruiting

• 1 other identifier: 43401
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative cognitive decline is a recognized complication following anesthesia and surgery in older adults; however, its incidence after ambulatory cataract surgery performed under sedation is not well understood. This prospective observational study aims to determine the proportion of patients aged 65 years and older who develop postoperative cognitive decline at 3 weeks and 3 months following ambulatory cataract surgery. Participants will complete a baseline Tele-Montreal Cognitive Assessment (T-MoCA) before surgery and repeat the assessment remotely at 3 weeks and 3 months after surgery. Demographic, medical, anesthetic, and procedural data will also be collected. The findings will improve understanding of postoperative cognitive outcomes in elderly patients undergoing ambulatory cataract surgery and help identify patients who may be at increased risk for postoperative cognitive decline.

Conditions

Post-Operative Cognitive Decline in Older Adults; Post-operative Cognitive Decline; Perioperative Neurocognitive Disorders; Cataract Surgery Anesthesia

Keywords

perioperative neurocognitive disorders; POCD; T-MoCa; Tele-Montreal Cognitive Assessment; Cataract surgery; anesthesia

Outcome Measures

Primary Outcomes (1)

• Proportion of patients with postoperative cognitive decline following sedation for ambulatory cataract surgery

  The proportion of participants who demonstrate postoperative cognitive decline, defined as a decline of one standard deviation or greater from their baseline Tele-Montreal Cognitive Assessment (T-MoCA) score, assessed at 3 weeks and 3 months following ambulatory cataract surgery performed under sedation.

  3 months post-operatively

Study Arms (1)

Older Adults Undergoing Ambulatory Cataract Surgery

Participants aged 65 years and older undergoing ambulatory cataract surgery under sedation at the Kensington Eye Institute. This is a prospective observational cohort study in which participants will receive standard perioperative care without any study-specific intervention. Cognitive function will be assessed using the Tele-Montreal Cognitive Assessment (T-MoCA) before surgery and again at 3 weeks and 3 months after surgery to evaluate postoperative cognitive decline.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing ambulatory cataract surgery at the Kensington Eye Institute (KEI).

You may qualify if:

• \. All patients ages 65 and older

You may not qualify if:

• Inability to understand instructions in English
• Lack of access to a computer, tablet, smartphone, or internet access
• Patients with established cognitive deficit diagnoses (e.g. Alzheimer's, TBI, stroke)
• Patients with known psychiatric diagnoses
• Patients who have undergone any procedure or surgery requiring sedation, regional, neuraxial or general anesthesia within the past 6 months

Sponsors & Collaborators

• Samuel Lunenfeld Research Institute, Mount Sinai Hospital: lead
• Mount Sinai Hospital, Canada: collaborator
• Kensington Eye Institute: collaborator

Study Sites (1)

Kensington Eye Institute

Toronto, Ontario, m5v3v2, Canada

Location

Study Officials

• Naveed Siddiqui, MD

  MOUNT SINAI HOSPITAL

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Naveed Siddiqui Associate Professor, MD

CONTACT

416-586-4800; naveed.siddiqui@uhn.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 15, 2026
• First Posted: July 20, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): November 1, 2027
• Study Completion (Estimated): November 1, 2027
• Last Updated: July 20, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)