Effects of Creatine and Carbohydrate Supplementation on Endurance Performance

NCT07712653 | Not Yet Recruiting

• 1 other identifier: 2013-CP
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the independent and combined effects of creatine and carbohydrate supplementation on exercise performance, compared to placebo.

Conditions

Exercise Performance Recovery

Outcome Measures

Primary Outcomes (1)

• Exercise Time to exhaustion

  Time to exhaustion (seconds) during continuous cycling performed at 60% of each participant's maximal cycling power output following supplementation with placebo, creatine monohydrate, or creatine monohydrate plus carbohydrate.

  Change in exercise time to exhaustion ( in seconds) through study completion, over the course of study completion, on average 4 weeks.

Study Arms (4)

Placebo

PLACEBO COMPARATOR

Flavored water every 20 minutes

Dietary Supplement: placebo solution

Creatine monohydrate

EXPERIMENTAL

Creatine Monohydrate supplementation every 0.5 grams every 20 minutes

Dietary Supplement: Creatine Monohydrate

Carbohydrate

EXPERIMENTAL

Carbohydrate supplementation 5 grams every 20 minutes

Dietary Supplement: Carbohydrate

Creatine and Carbohydrate

EXPERIMENTAL

Creatine supplementation at 0.5 gram and carbohydrate supplementation of 5 grams every 20 minutes

Dietary Supplement: Creatine Monohydrate and Carbohydrate

Interventions

Carbohydrate DIETARY_SUPPLEMENT

carbohydrate supplementation 5 grams every 20 minutes

Carbohydrate

Creatine Monohydrate DIETARY_SUPPLEMENT

Creatine monohydrate supplementation 0.5 grams every 20 minutes

Creatine monohydrate

Creatine Monohydrate and Carbohydrate DIETARY_SUPPLEMENT

Creatine supplementation of 0.5 grams and carbohydrate supplementation of 5 grams every 20 minutes.

Creatine and Carbohydrate

placebo solution DIETARY_SUPPLEMENT

Flavored water every 20 minutes

Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy (i.e. no known cardiovascular disease)
• nonsmoking
• active (regular physical activity ≥150 minutes per week of aerobic exercise and have a VO2 peak ≥35 ml/kg-min)
• a normal BMI (18.5 - 35 kg/m\^2)
• between ages 18-40 years old

You may not qualify if:

• previously taken creatine and/or any other dietary supplement that may interfere with exercise performance

Sponsors & Collaborators

• California Polytechnic State University-San Luis Obispo: lead

Study Sites (1)

California Polytechnic State University

San Luis Obispo, California, 93407, United States

Location

MeSH Terms

Interventions

Creatine; Carbohydrates

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Central Study Contacts

Todd Hagobian, PhD

CONTACT

805-756-7511; thagobia@calpoly.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department Chair and Professor

Study Record Dates

• First Submitted: July 8, 2026
• First Posted: July 17, 2026
• Study Start: July 15, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: July 21, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: August 1, 2026
• Access Criteria: Available to download

Locations

US (1)