Effect of GMI With and Without NM on LE in Cancer Patients With CIPN

NCT07712302 | Completed

• 1 other identifier: TUF/IRB/98/2025
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this interventional study is to learn if graded motor imagery with or without added neural mobilization can treat chemotherapy induced nerve related symptoms in lower limbs of cancer patients. The main questions it aims to answer are: \- Does graded motor imagery yields any added effects in relieving nerve related symptoms due to chemotherapy in lower limbs of cancer patients to the effects of nerve mobilization? Researchers will compare the effects of graded motor imagery as a standalone therapy (Group A) to the effects of graded motor imagery with nerve mobilization (Group B) Participants will take treatment sessions according to their allocated group, two sessions per week for six weeks.

Conditions

Chemotherapy Induced Peripheral Neuropathy (CIPN); Cancer

Keywords

Cancer, Neural Mobilization, Graded Motor Imagery, Neuropathic pain, Nerve gliding, Chemotherapy Induced Peripheral Neuropathy, Sensory Ataxia

Outcome Measures

Primary Outcomes (1)

• LANSS

  Leeds Assessment of Neuropathic Symptoms and Sign

  Baseline, week 3 (mid-intervention), week 6 (post intervention)

Secondary Outcomes (2)

• Romberg Test

  Baseline, week 6 (post-intervention)

• EORTC-QLQ-CIPN20

  Baseline, week 6 (post-intervention)

Study Arms (2)

Group A - Graded Motor Imagery

EXPERIMENTAL

Graded motor imagery sessions were provided twice a week for six weeks. Each GMI phase lasted for two weeks.

Other: Graded Motor Imagery

Group B - Grade Motor Imagey with Neural Mobilization

ACTIVE COMPARATOR

Graded motor imagery with neural mobilization sessions were provided twice a week for six weeks.

Other: Graded Motor Imagery; Other: Neural Mobilization

Interventions

Graded Motor Imagery OTHER

Graded motor imagery is a series of three steps. The first step, lateral recognition, includes graded left and right judgment exercises. The second step involves imagining the performance of movements and the third, and last step involves performing movements in front of a mirror.

Group A - Graded Motor Imagery; Group B - Grade Motor Imagey with Neural Mobilization

Neural Mobilization OTHER

Nerve mobilization allows movement between structures of nervous system and its surrounding areas. It is used to mobilize the nervous system and maintain equilibrium inside the nervous system as well as in structures present in its surroundings.

Group B - Grade Motor Imagey with Neural Mobilization

Eligibility Criteria

• Age: 31 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both male and female
• Age ranging from 31 to 65 years
• Diagnosed cancer patients (stage 1 to 3, cancer of any kind)
• Chemotherapy sessions (antineoplastic drugs) - at least 1 session
• Presence of glove and stocking peripheral neuropathy
• LANSS score greater than 12
• Agreed to give complete follow-up

You may not qualify if:

• Any co-morbid conditions that can cause peripheral neuropathy e.g. diabetes, chronic kidney failure
• Any trauma history that can cause peripheral neuropathic symptoms
• Pre-existing nerve entrapment syndromes
• Diagnosed stage 4 cancer patients
• Cancer patients taking palliative chemotherapy

Sponsors & Collaborators

• University of Faisalabad: lead

Study Sites (1)

The University of Faisalabad

Faisalābad, Punjab Province, 38000, Pakistan

Location

MeSH Terms

Conditions

Neoplasms; Neuralgia; Ataxia

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Dyskinesias

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Group A was given graded motor imagery Group B was given graded motor imagery with neural mobilization

Study Record Dates

• First Submitted: July 14, 2026
• First Posted: July 17, 2026
• Study Start: March 1, 2025
• Primary Completion: June 6, 2025
• Study Completion: June 6, 2025
• Last Updated: July 17, 2026

Record last verified: 2026-07

Locations

PA (1)