NCT07710209

Brief Summary

To determine the efficacy of IASTM as an adjunct to therapeutic exercises on pain, range of motion, and functional performance in individuals with knee OA.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2025

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2025

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

July 11, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 17, 2026

Completed
Last Updated

July 17, 2026

Status Verified

July 1, 2026

Enrollment Period

11 months

First QC Date

July 11, 2026

Last Update Submit

July 15, 2026

Conditions

Knee Osteoarthritis (OA)

Keywords

Knee osteoarthritis; Instrument-assisted soft tissue mobilization; Therapeutic exercise; Randomized controlled trial; Functional outcomes

Outcome Measures

Primary Outcomes (3)

  • Numeric Pain Rating Scale (NPRS)

    The value were taken at base line and after 6 weeks of intervention

    6 weeks

  • Knee range of motion (goniometry)

    The value were taken at base line and after 6 weeks of intervention

    6 weeks

  • Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

    The value were taken at base line and after 6 weeks of intervention

    6 weeks

Study Arms (2)

IASTM Combined with a Standardized Therapeutic Exercise Protocol

EXPERIMENTAL

IASTM Combined with a Standardized Therapeutic Exercise Protocol: Treatment was administered three times per week for 6 weeks

Behavioral: IATSM

Therapeutic Exercise Protocol

EXPERIMENTAL

Therapeutic Exercise Protocol: Treatment was administered three times per week for 6 weeks

Behavioral: Therapeutic Exercise

Interventions

IATSMBEHAVIORAL

IATSM were administered for a duration of 6 weeks

IASTM Combined with a Standardized Therapeutic Exercise Protocol
Therapeutic ExerciseBEHAVIORAL

Therapeutic Exercise were administered for a duration of 6 weeks

Therapeutic Exercise Protocol

Eligibility Criteria

Age40 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

FMRL

Karachi, Sindh, Pakistan

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Exercise Therapy

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Intervention Hierarchy (Ancestors)

RehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy Modalities

Study Officials

  • Malika Hassan

    fmr.labs@medicalresearchforum.net

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 11, 2026

First Posted

July 17, 2026

Study Start

February 1, 2025

Primary Completion

December 31, 2025

Study Completion

December 31, 2025

Last Updated

July 17, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations

PA(1)