Functional Hip Strength Improvement in Knee Osteoarthritis Following Single-Dose PRP and a 6-Week Home Exercise Program

NCT07307118 | Completed DMC

• 1 other identifier: FU_MGBeydagi_PRP_B_2025/12/150
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

This single-group longitudinal study evaluated changes in hip stability isometric strength, knee muscle strength, and activity-related pain in women with knee osteoarthritis following a single-dose intra-articular platelet-rich plasma (PRP) injection and a 6-week home exercise program. Outcomes were assessed at baseline (5 days post-injection), week 6, and week 12. The intervention included strengthening exercises for knee and hip muscle groups performed three times per week and regular walking encouragement with weekly phone follow-up for adherence.

Conditions

Knee Osteoarthritis (OA)

Keywords

Knee osteoarthritis; exercise therapy; hip muscle strength; platelet-rich plasma; Hand-held dynamometer; Pain

Outcome Measures

Primary Outcomes (1)

• Hip Stability Isometric Test (HipSIT) strength (N/kg), affected side

  Hip stability isometric strength (combined hip extensor, abductor and external rotator maximum isometric strength) assessed using a hand-held dynamometer during the Hip Stability Isometric Test (HipSIT). The test is performed in side-lying "clam" position (hip 45° flexion, knee 90° flexion). Three maximal trials (5 seconds each) are performed and the maximum force output (N) is normalized to body mass (N/kg).

  Baseline (5 days post PRP injection), Week 6, Week 12

Secondary Outcomes (3)

• Quadriceps femoris isometric strength (N/kg), affected side

  Baseline (5 days post PRP injection), Week 6, Week 12

• Hamstring isometric strength (N/kg), affected side

  Baseline (5 days post PRP injection), Week 6, Week 12

• Knee pain during activity (Visual Analog Scale, 0-10)

  Baseline (5 days post PRP injection), Week 6, Week 12

Other Outcomes (1)

• Strength symmetry indices (QI, HI, HipI), %

  Baseline (5 days post PRP injection), Week 6, Week 12

Study Arms (1)

Single Group: PRP Injection + Home Exercise Program

EXPERIMENTAL

All participants received a unilateral single-dose intra-articular platelet-rich plasma (PRP) injection for symptomatic knee osteoarthritis, followed by a 6-week home-based strengthening and functional exercise program performed 3 times per week. The exercise program targeted knee extensors/flexors and hip extensors/abductors/external rotators. Participants were encouraged to walk at least 30 minutes on at least 5 days per week and were contacted weekly by phone to support adherence.

Biological: Platelet-Rich Plasma (PRP) Injection; Behavioral: Home Exercise Program

Interventions

Platelet-Rich Plasma (PRP) Injection BIOLOGICAL

A single unilateral intra-articular autologous platelet-rich plasma (PRP) injection was administered to the affected knee. Baseline assessments were conducted 5 days following the injection.

Also known as: PRP

Single Group: PRP Injection + Home Exercise Program

Home Exercise Program BEHAVIORAL

Home-based exercise program performed 3 times per week for 6 weeks, designed to strengthen knee extensors/flexors and hip extensors/abductors/external rotators. Exercises included: quadriceps strengthening (supine isometric contractions with 5-second hold; seated knee extension with 5-second hold; straight leg raise with 5-second hold), hamstring strengthening (supine isometric contractions with 5-second hold; prone active knee flexion with 5-second hold), hip stabilizer strengthening (clamshells and side-lying hip abduction with 5-second hold), and functional exercises (step-ups, forward touchdowns from a step, side stepping, sit-to-stand from a chair without using arms, and partial wall squats), typically 10-15 repetitions. Participants were also encouraged to walk at least 30 minutes on at least 5 days per week, and adherence was supported via weekly telephone contact.

Single Group: PRP Injection + Home Exercise Program

Eligibility Criteria

• Age: 45 Years - 70 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female patients aged 45-70 years.
• Radiographic knee osteoarthritis: Kellgren-Lawrence grade II-III in the affected knee and grade II or less in the unaffected knee.
• Unilateral knee pain during activity with VAS score ≥5 (for at least the past 3 months).
• Referred to physiotherapy following a unilateral single-dose PRP injection.

You may not qualify if:

• Any intra-articular knee injection within the past 6 months.
• Regular lower-extremity strengthening exercise or non-pharmacological treatment for knee OA within the past 6 weeks.
• History of lower-extremity surgery.
• History of neurological, rheumatological and/or cognitive diseases.
• Unable to use a telephone.

Sponsors & Collaborators

• Firat University: lead

Study Sites (1)

Fırat Üniversitesi

Elâzığ, MErkez, 23200, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Pain

Interventions

Injections

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Drug Administration Routes; Drug Therapy; Therapeutics

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Single Group Assignment

Study Record Dates

• First Submitted: December 13, 2025
• First Posted: December 29, 2025
• Study Start: July 8, 2025
• Primary Completion: December 12, 2025
• Study Completion: December 13, 2025
• Last Updated: December 29, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)