CHATEAU Registry: Clinical Outcomes After Transcatheter Aortic Valve Replacement

NCT07709858 | Recruiting

• 1 other identifier: CHATEAU-REG-001
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a multicenter, retrospective registry study using the CHATEAU Registry. The study will evaluate patients who underwent transcatheter aortic valve replacement between January 2021 and December 2025. The purpose of the study is to assess clinical outcomes and valve performance after TAVR in real-world practice, with a focus on procedural strategies, valve-related factors, and long-term outcomes. Patient clinical information, imaging findings, procedural data, echocardiographic results, and follow-up outcomes will be collected from existing medical records. No additional intervention, treatment, or study-specific visit will be performed.

Conditions

Aortic Valve Stenosis; Transcatheter Aortic Valve Replacement (TAVR)

Keywords

CHATEAU Registry; Transcatheter Aortic Valve Replacement; TAVR; Aortic Stenosis; Real-world Data; Valve Performance; Clinical Outcomes; Multicenter Registry

Outcome Measures

Primary Outcomes (1)

• All-Cause Mortality

  Death from any cause occurring after transcatheter aortic valve replacement (TAVR) during follow-up.

  From the index TAVR procedure through December 31, 2027 (up to approximately 6 years)

Secondary Outcomes (1)

• Cardiovascular Mortality Stroke Heart Failure Hospitalization Myocardial Infarction Aortic Valve Reintervention Valve Hemodynamic Deterioration Prosthetic Valve Endocarditis/thrombosis Permanent pace maker insertion Major Bleeding

  From the index TAVR procedure through December 31, 2027 (up to approximately 6 years)

Study Arms (1)

CHATEAU Registry Cohort

Consecutive adult patients with severe aortic valve disease who underwent transcatheter aortic valve replacement (TAVR) between January 1, 2021 and December 31, 2025 at participating centers in the CHATEAU Registry. Clinical, imaging, procedural, and follow-up data are collected retrospectively from routine clinical practice.

Procedure: Transcatheter Aortic Valve Replacement

Interventions

Transcatheter Aortic Valve Replacement PROCEDURE

Transcatheter aortic valve replacement (TAVR) performed according to routine clinical practice using commercially available transcatheter heart valves and standard procedural techniques at participating centers.

CHATEAU Registry Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of consecutive adult patients who underwent clinically indicated transcatheter aortic valve replacement (TAVR) for severe native aortic valve disease at participating centers in the CHATEAU Registry. Clinical, imaging, procedural, echocardiographic, and follow-up data are retrospectively collected from routine clinical practice to evaluate long-term clinical outcomes and prosthetic valve performance in a real-world international cohort.

You may qualify if:

• Adults (≥18 years of age).
• Patients who underwent transcatheter aortic valve replacement (TAVR) for severe native aortic valve disease at participating centers.
• TAVR performed between January 1, 2021 and December 31, 2025.
• Availability of baseline procedural and follow-up clinical data in the institutional registry or medical records.

You may not qualify if:

• Patients with insufficient clinical or procedural data for outcome assessment.

Sponsors & Collaborators

• Eunpyeong St. Mary's Hospital: lead
• RCF@ICPS: collaborator
• Kokura Memorial Hospital: collaborator

Study Sites (1)

The Catholic University of Korea, Eunpyeong St. Mary's Hospital

Seoul, 03312, South Korea

RECRUITING

MeSH Terms

Conditions

Aortic Valve Stenosis

Interventions

Transcatheter Aortic Valve Replacement

Condition Hierarchy (Ancestors)

Aortic Valve Disease; Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases; Ventricular Outflow Obstruction

Intervention Hierarchy (Ancestors)

Heart Valve Prosthesis Implantation; Cardiac Surgical Procedures; Cardiovascular Surgical Procedures; Surgical Procedures, Operative; Prosthesis Implantation; Thoracic Surgical Procedures

Study Officials

• Osung Kwon, MD, PhD

  The Catholic University of Korea Eunpyeong St. Mary's Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Osung Kwon, MD. PhD

CONTACT

+821037085673; oscaesar@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 12, 2026
• First Posted: July 17, 2026
• Study Start: January 1, 2021
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: July 17, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)