BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927)

NCT07707297 | Recruiting

• 1 other identifier: BIOANCIENT
• Study Type: observational
• Target: 333
• Locations: 1 country
• Sites: 1

Brief Summary

Demographic aging is a growing global challenge, driven by increasing life expectancy and declining birth rates, with projections indicating that more than 30% of the European population will be over 65 years old by 2100. Centenarians represent a unique biological model of extreme longevity, often exhibiting delayed onset of age-related diseases and preserved functional capacity. This study aims to establish an intergenerational cohort of centenarians in Navarra (Spain) to investigate the biological, clinical, environmental, and lifestyle factors associated with extreme longevity. By integrating multidimensional data-including clinical assessments, functional and cognitive measures, and biological markers-this study seeks to improve understanding of aging mechanisms and identify potential determinants of healthy aging.

Conditions

Aging; Cellular Senescence; Biomarkers / Blood; Age-Related Diseases; Frailty

Keywords

Centenarians; Healthy aging; Senescence; Geroscience; Age-related diseases; Longevity; Senescence biomarkers; Personalized medicine; Preventive medicine; Artificial intelligence in healthcare; Omics technologies (genomics, proteomics, metabolomics)

Outcome Measures

Primary Outcomes (1)

• Integrated biological aging profile based on clinical and multi-omics biomarkers.

  Clinical, funtional and molecular characterization of centenarian individuals using multi-omics biomarkers

  Baseline and 1-year follow-up

Secondary Outcomes (37)

• Cognitive Function assessed with Mini Mental State Examination (MMSE)

  Baseline and 1-year follow-up

• Functional status measured with Barthel Index

  Baseline and 1-year follow-up

• Physical function assessed by Short Physical Performance Battery (SPPB)

  Baseline and 1-year follow-up

• Frailty assessed by Fried Frailty Phenotype

  Baseline and 1-year follow-up

• Lawton Instrumental Activities of Daily Living (IADL)

  Baseline and 1-year follow-up

Other Outcomes (3)

• Baseline Demographics and Socio-Environmental Profile

  Baseline

• Lifestyle Factors

  Baseline (single assessment)

• Other Geriatric Syndromes and Health Dimensions

  Baseline and 1-year follow-up

Study Arms (1)

Centenarians resident in Navarre - Spain

Centenarians (individuals aged ≥100 years) residing in Navarre, Spain.

Eligibility Criteria

• Age: 100 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of very old adults aged 100 years and older residing in Navarre, Spain. Participants will be community-dwelling or institutionalized individuals who meet the inclusion criteria and are able to undergo a comprehensive geriatric assessment. The study aims to include a representative sample of the centenarian population in the region.

You may qualify if:

• Individuals aged ≥100 years
• Residents of Navarre, Spain

You may not qualify if:

• Clinical decompensation within the last month, including hemodynamic instability, acute illness, or hospitalization;
• End-of-life condition, defined as a clinical state of irreversible deterioration with a life expectancy of days to weeks, as determined by a physician.

Sponsors & Collaborators

• Fundacion Miguel Servet: lead
• Gobierno de Navarra: collaborator

Study Sites (1)

Navarrabiomed

Pamplona, Navarre, 31001, Spain

RECRUITING

Related Links

• Information about the project

MeSH Terms

Conditions

Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Nicolas Martínez Velilla, MD and PhD

  Navarrabiomed, Hospital Universitario de Navarra, IdisNa, Universidad Pública de Navarra

  PRINCIPAL INVESTIGATOR

• Chenhui Chen, MD

  Navarrabiomed, Hospital Universitario de Navarra, IdisNa, Universidad Pública de Navarra

  STUDY DIRECTOR

• Enrique Santamaría, PhD

  Navarrabiomed, Hospital Universitario de Navarra, IdisNa, Universidad Pública de Navarra

  STUDY CHAIR

Central Study Contacts

Nicolás Martínez Velilla, MD and PhD

CONTACT

+34 848 422 287; nicolas.martinez.velilla@navarra.es

Fabíola Zambom Ferraresi, PhD

CONTACT

+34 848 422 521; fabiola.zambom.ferraresi@navarra.es

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 18, 2026
• First Posted: July 16, 2026
• Study Start: February 4, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: July 16, 2026

Record last verified: 2026-07

Locations

ES (1)