Blood Flow Restriction and Aerobic Exercise in Iron Deficiency Anemia

NCT07701213 | Not Yet Recruiting

• 1 other identifier: P.T.REC/012/006440
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this issue.

Conditions

Iron Deficiency Anaemia

Keywords

Iron Deficiency Anemia; blood flow restriction

Outcome Measures

Primary Outcomes (6)

• haemoglobin concentration

  Baseline and 12 weeks

• Serum ferritin level

  Baseline and at 12 weeks

• Haematocrit

  Baseline and at 12 weeks

• Red blood cell (RBC) count

  baseline and at 12 week

• Mean corpuscular volume (MCV)

  baseline and at 12 week

• Mean corpuscular haemoglobin (MCH)

  baseline and at 12 week

Secondary Outcomes (3)

• Functional capacity assessed using the Incremental Shuttle Walk Test (ISWT)

  baseline and at 12 week

• Quality of life assessed using the SF-36 questionnaire

  baseline and at 12 week

• Estimated maximal oxygen consumption (VO₂max) derived from the ISWT

  baseline and at 12 week

Study Arms (2)

Aerobic Exercise + Blood Flow Restriction

EXPERIMENTAL

25 female will receive blood flow restriction with low intensity aerobic exercise participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group.

Device: aerobic exercise + blood flow restriction

Aerobic Exercise

ACTIVE COMPARATOR

25 subject participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down.

Procedure: aerobic exercise

Interventions

aerobic exercise + blood flow restriction DEVICE

Twenty five females will be subjected to supervised blood flow restriction combined with aerobic exercise program. participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes .A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. The pressure of the cuff was increased until the participants adapted to the restriction stimulus during the early phase of training, and this pressure was maintained used during the training protocol. The strap pressure was increased by 10 mmHg per week, such that it reached 200 mmHg by the end of 12th week. The pressure on the thigh strap was abruptly released after five completions of the exercise set.

Aerobic Exercise + Blood Flow Restriction

aerobic exercise PROCEDURE

participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down.

Aerobic Exercise

Eligibility Criteria

• Age: 19 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Hb more than 8 and less than 12 in females.
• Age: 19-25 year.
• BMI ranging from 25 to 29.9 kg/m2.
• No existing inflammatory conditions including rheumatoid arthritis disorders of the lower extremities.
• Physical activity level less than 150 min per week

You may not qualify if:

• unstable hypertension, venous thromboembolism, hypercoagulable states, varicose veins, pregnancy, and hemophilia.
• inherited or acquired red cell disorders (haemoglobinopathies).
• acute or chronic infections (malaria, tuberculosis, HIV),.
• severe anemia (Hb \<8 g/dL).
• History of cardiovascular diseases.
• Nutritional anemia (B12/folate)
• Pregnancy.
• Peripheral arterial disease.
• Intermittent claudication.
• Non smokers

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Conditions

Anemia, Iron-Deficiency

Interventions

Exercise

Condition Hierarchy (Ancestors)

Anemia, Hypochromic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Iron Deficiencies; Iron Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

noha sameh donia, assisstant lecturer

CONTACT

01275600448; nohasameh92.ns@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant lecturer

Study Record Dates

• First Submitted: July 2, 2026
• First Posted: July 14, 2026
• Study Start: July 25, 2026
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): November 5, 2026
• Last Updated: July 14, 2026

Record last verified: 2026-07